4 January 2023

COVID drug Paxlovid was hailed as a game-changer. What happened? Insufficient investment and fears about rebound and side effects are driving down use of a lifesaving antiviral. https://www.nature.com/articles/d41586-022-04576-6

A Valuable COVID Drug Doesn’t Work against New Variants. Current monoclonal antibodies fail against COVID virus variants, so drugmakers want to use a fast-track test for new ones. https://www.scientificamerican.com/article/a-valuable-covid-drug-doesnt-work-against-new-variants/

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants.https://www.cell.com/cell/fulltext/S0092-8674(22)01531-8

Examination of Adverse Reactions After COVID-19 Vaccination Among Patients With a History of Multisystem Inflammatory Syndrome in Children.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799939

Vaccine inequity and hesitancy persist—we must tackle both.https://www.bmj.com/content/380/bmj.p8

Omicron B.1.1.529 variant infections associated with severe disease are uncommon in a COVID-19 under-vaccinated, high SARS-CoV-2 seroprevalence population in Malawi.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00529-6/fulltext

OTHER NEWS

Cancer survival in Africa, central and south America, and Asia (SURVCAN-3): a population-based benchmarking study in 32 countries. Disparities in cancer survival across countries were linked to a country’s developmental position, and the availability and efficiency of health services. These data can inform policy makers on priorities in cancer control to reduce apparent inequality in cancer outcome. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00704-5/fulltext

Is my study useless? Why researchers need methodological review boards. Making researchers account for their methods before data collection is a long-overdue step.https://www.nature.com/articles/d41586-022-04504-8

Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration. A Randomized Clinical Trial.https://jamanetwork.com/journals/jama/fullarticle/2800025

Converting Steps Into Physical Activity Time.https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800155

Converting Steps Into Physical Activity Time—Reply.https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800154

Unlocking the Promise of Physical Activity for Mental Health Promotion.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2799813

Association of Habitual Checking Behaviors on Social Media With Longitudinal Functional Brain Development. The results of this cohort study suggest that social media checking behaviors in early adolescence may be associated with changes in the brain’s sensitivity to social rewards and punishments. Further research examining long-term associations between social media use, adolescent neural development, and psychological adjustment is needed to understand the effects of a ubiquitous influence on development for today’s adolescents. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2799812

Promoting physician-patient language concordance in undergraduate medical education: a peer assisted learning approach.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03986-4

Auditing the quality of epidemic decision-making in Somalia: a pilot evaluation.https://bmjopen.bmj.com/content/13/1/e065122

Pasteurisation: Pasteur’s greatest contribution to health.https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00324-X/fulltext

Health and cancer risks associated with low levels of alcohol consumption. https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00317-6/fulltext#%20

Advancement of asthma management in the past decade.https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00496-9/fulltext

The effect of parental leave on parents’ mental health: a systematic review.https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00311-5/fulltext?utm_content=233496425&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292

Ultrasound-Guided Interventions. Manual of Resource-Limited Surgery. https://www.vumc.org/global-surgical-atlas/sites/default/files/public_files/PDF/Ultrasound-Guided%20Interventions.pdf

FROM 3 JAN

Research Upends Conventional Wisdom about How We Burn Calories. Metabolism studies reveal surprising insights into how we burn calories—and how cooperative food production helped Homo sapiens flourish.https://www.scientificamerican.com/article/new-human-metabolism-research-upends-conventional-wisdom-about-how-we-burn-calories/

How Diet Builds Better Bones: Surprising Findings on Vitamin D, Coffee, and More. For healthy adults who want strong bones, a commonly recommended vitamin doesn’t seem to help, but other things really do.https://www.scientificamerican.com/article/how-diet-builds-better-bones-surprising-findings-on-vitamin-d-coffee-and-more/

Performance of Cardiovascular Risk Prediction Models Among People Living With HIV. A Systematic Review and Meta-analysis.https://jamanetwork.com/journals/jamacardiology/fullarticle/2800100

Science and ART—Cardiovascular Disease Risk Assessment in HIV.https://jamanetwork.com/journals/jamacardiology/fullarticle/2800105

Children and adolescents with physical disabilities: describing characteristics and disability-related needs in the Kilimanjaro region, north-eastern Tanzania – a cross-sectional survey. https://bmjopen.bmj.com/content/13/1/e064849

The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00423-5/fulltext

Small airways obstruction and its risk factors in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00456-9/fulltext

Prophylactic use of incisional negative pressure wound therapy for the prevention of surgical site occurrences in general surgery: Consensus document.https://www.surgjournal.com/article/S0039-6060(22)01012-1/fulltext?dgcid=raven_jbs_aip_email#%20

Universal health coverage cannot be universal without oral health.https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00315-2/fulltext?utm_campaign=comment22&utm_content=233357352&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292

Global Disparities in Burn Outcomes: Does Gender Predict Mortality in the Global Burn Registry? Female burn patients suffer higher mortality compared to males and are less likely to receive surgery. https://www.sciencedirect.com/science/article/pii/S0022480422007016?dgcid=coauthor

The impact of social determinants of health on the overall wellbeing of children: A review for the pediatric surgeon. https://www.jpedsurg.org/article/S0022-3468(21)00728-4/fulltext?rss=yes

Rivaroxaban: Lancet opens investigation into anticlotting drug trial after BMJ report.https://www.bmj.com/content/379/bmj.o3071

We Asked the Experts: Innovative Venture Investing as a Model for Strengthening Global Surgery. https://link.springer.com/article/10.1007/s00268-022-06774-9?utm_source=toc&utm_medium=email&utm_campaign=toc_268_47_2&utm_content=etoc_springer_20221231

5 JAN 2023

Study: Short Spurts of Vigorous Physical Activity During Daily Life Are Associated With Lower Mortality. https://jamanetwork.com/journals/jama/fullarticle/2800314?guestAccessKey=102ad61c-ce34-4657-a9e8-a664d8d087f5&utm_source=twitter&utm_medium=social_jama&utm_term=8550431738&utm_campaign=article_alert&linkId=195999229

Audio Interview: The Expanding Arsenal of Oral Agents to Treat Covid-19.https://www.nejm.org/doi/full/10.1056/NEJMe2300069?query=featured_home

Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB.https://www.nejm.org/doi/full/10.1056/NEJMc2214302?query=featured_home

Efficacy of Combined Visual-Olfactory Training With Patient-Preferred Scents as Treatment for Patients With COVID-19 Resultant Olfactory Loss. A Randomized Clinical Trial. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2799843

Perception from students regarding online synchronous interactive teaching in the clinical year during COVID-19 pandemic.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03958-8

Post-traumatic stress disorders and coping strategies of health professionals during COVID-19 pandemic in Bangladesh: findings of a countrywide cross-sectional study.https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00148-2/fulltext

Manufacture and Characterization of GMP-Compliant SARS-COV-2 Cytotoxic T Lymphocytes. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac500/6965956?searchresult=1

Lessons from Nigeria’s Adaptation of Global Health Initiatives during the COVID-19 Pandemic. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745227/

OTHER NEWS

Cancer survival in Africa, central and south America, and Asia (SURVCAN-3): a population-based benchmarking study in 32 countries.https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00704-5/fulltext

Classroom assistance: the scientists turning the tools of their trade to education. A small but growing number of scientific faculty positions are focusing on the science of teaching. https://www.nature.com/articles/d41586-022-04509-3

Study: Short Spurts of Vigorous Physical Activity During Daily Life Are Associated With Lower Mortality. https://jamanetwork.com/journals/jama/fullarticle/2800314

Risk Factors for Hearing Loss at Birth in Newborns With Congenital Cytomegalovirus Infection. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2799844

Association of a Liberal Fasting Policy of Clear Fluids Before Surgery With Fasting Duration and Patient Well-being and Safety. Results suggest that surgical procedures in patients who drink clear fluids within 2 hours before anticipated anesthesia should not be postponed or canceled. https://jamanetwork.com/journals/jamasurgery/fullarticle/2799837

Association of Women Surgeons’ Comprehensive Initiative for Healthy Surgical Families During Residency and Fellowship Training.https://jamanetwork.com/journals/jamasurgery/fullarticle/2799835

An early analysis of the World Bank’s Pandemic Fund: a new fund for pandemic prevention, preparedness and response. https://gh.bmj.com/content/8/1/e011172

Investing in preparedness for rapid detection and control of epidemics: analysis of health system reforms and their effect on 2021 Ebola virus disease epidemic response in Guinea. https://gh.bmj.com/content/8/1/e010984

Meningococcal A conjugate vaccine coverage in the meningitis belt of Africa from 2010 to 2021: A modelling study.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00526-0/fulltext

The effect of parental leave on parents’ mental health: a systematic review.https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00311-5/fulltext

Embedding Indigenous knowledges and voices in planetary health education.https://www.thelancet.com/journals/lanplh/article/PIIS2542-5196(22)00308-4/fulltext

Policy Report: Subsidizing global health: Women’s unpaid work in health systems.https://womeningh.org/our-advocacy/paywomen/

Ergonomic considerations in urology. https://link.springer.com/epdf/10.1007/s11934-022-01142-5?sharing_token=UfzNSvBwtD6dZaIq4lroHfe4RwlQNchNByi7wbcMAY7kRGwkGed1W30DhAi-Nw1dIgBiMzI_SeZwnWV18GOGx9ClVsgoAcFlHNIksnNSQYWiLO6S-XBZrpCD2VufwnLVXCQVVJuDRuFzF6ZpjFrmDAMnG0Ei8lqoJ4W49Wz4ETQ%3D

Bridging the gender gap in childhood cancer: a call to action.https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00741-0/fulltext

6 JAN 2023

Face masks while exercising trial (MERIT): a cross-over randomised controlled study.This study adds to previous findings (mostly from non-randomised studies) that exercising at moderate-to-high intensity wearing a face mask appears to be safe in healthy, young adults. https://bmjopen.bmj.com/content/13/1/e063014

Nirmatrelvir Plus Ritonavir for Early COVID-19 in a Large U.S. Health System. A Population-Based Cohort Study. https://www.acpjournals.org/doi/10.7326/M22-2141?utm_source=TFA&utm_campaign=1222&utm_content=TFA202212&cmp=1&utm_medium=email

The Association Between COVID-19 and Lung Function: A Mendelian Randomization Analysis. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad002/6972542?searchresult=1

Complications, Adverse Drug Events, High Costs, and Disparities in Multisystem Inflammatory Syndrome in Children vs COVID-19.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800087

Disparities in Multisystem Inflammatory Syndrome in Children and COVID-19 Across the Organ Dysfunction Continuum.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800089

Household living conditions and food insecurity in Nigeria: a longitudinal study during COVID-19 pandemic. https://bmjopen.bmj.com/content/13/1/e066810

Telehealth use in Australian primary healthcare during COVID-19: a cross-sectional descriptive survey. https://bmjopen.bmj.com/content/13/1/e065478

Understanding COVID-19 reporting behaviour to support political decision-making: a retrospective cross-sectional study of COVID-19 data reported to WHO.https://bmjopen.bmj.com/content/13/1/e061717

The role of ECMO in COVID-19 acute respiratory failure: Defining risk factors for mortality. https://www.americanjournalofsurgery.com/article/S0002-9610(22)00799-1/fulltext

Vaccination with Span, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice.https://www.science.org/doi/10.1126/scitranslmed.abo3332

Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.https://www.science.org/doi/10.1126/sciadv.ade8272

OTHER NEWS

Global estimates of the number of pregnancies at risk of malaria from 2007 to 2020: a demographic study. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00431-4/fulltext

Energy in 2023 and editorial changes. https://www.science.org/doi/10.1126/science.adg4111

Analysis of a Sabin-Strain Inactivated Poliovirus Vaccine Response to a Circulating Type 2 Vaccine-Derived Poliovirus Event in Sichuan Province, China 2019-2021.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800080

Unlocking the Promise of Physical Activity for Mental Health Promotion.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2799813

Patient and public involvement and engagement (PPIE) in healthcare education and thesis work: the first step towards PPIE knowledgeable healthcare professionals.https://bmjopen.bmj.com/content/13/1/e067588

Health interventions and the unseen impact on equality. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00268-9/fulltext#%20

Exploring medical students’ perspectives of physician leadership.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03971-x

“Antibiotic prescribing etiquette” an elective course for medical students: could we recruit potential physicians to fight resistance?https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03949-9

Drama Training as a Tool to Teach Medical Trainees Communication Skills: A Scoping Review.https://journals.lww.com/academicmedicine/Abstract/9900/Drama_Training_as_a_Tool_to_Teach_Medical_Trainees.316.aspx?utm_source=twitter&utm_medium=acadmedjournal&utm_content=0259873b-ee29-429a-b764-932a5a264051

Team Europe Takes on Global Health. A new and ambitious strategy. It prioritizes supporting low- and middle-income countries that are seeking health sovereignty. https://www.thinkglobalhealth.org/article/team-europe-takes-global-health?utm_source=tw_tgh&utm_medium=social_owned

9 JAN 2023

Wastewater surveillance for public health. Wastewater contains information on pathogen spread, evolution, and outbreak risk.https://www.science.org/doi/10.1126/science.ade2503

SARS-CoV-2 Omicron subvariants Spike recognition and neutralization elicited after the third dose of mRNA vaccine. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00009-8

Risk of within-hotel transmission of SARS-CoV-2 during on-arrival quarantine in Hong Kong: an epidemiological and phylogenomic investigation.https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(22)00293-0/fulltext

Risks and burdens of incident dyslipidaemia in long COVID: a cohort study.https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00355-2/fulltext

OTHER NEWS

Leveraging the South African Diabetes Prevention Programme to screen for chronic kidney disease: an observational study. https://bmjopen.bmj.com/content/13/1/e068672

Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa.https://assets.researchsquare.com/files/rs-2270584/v1/b9319179-1758-4e9e-bcf5-5afe1b559a16.pdf?c=1670446060

Infection after surgical implant generation network (SIGN) nailing in treatment of long bone shaft fractures in Ethiopia: analysis of a 4-year results.https://link.springer.com/article/10.1007/s00590-022-03454-1

Sleep quality among undergraduate medical students in Rwanda: a comparative study.https://www.nature.com/articles/s41598-023-27573-9.epdf?sharing_token=1LneVay1G7XYTCO4bFLN9NRgN0jAjWel9jnR3ZoTv0MqixoPJM5O_74i3iv4Hinwyf-z6BLIUQu0E-pRVsnkQiY3m6fJLOsrh3wx2ec2R4eOad3D5il-fjGHy1jRHjvLg59wR4rRHjZt4Tsaf4zKQCc5jmUiQsM-mAdbpF-SAt0%3D

Humanitarian paediatrics: A statement of purpose.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001431

Implementation research of a cluster randomized trial evaluating the implementation and effectiveness of intermittent preventive treatment for malaria using dihydroartemisinin‑piperaquine on reducing malaria burden in school‑aged children in Tanzania: methodology, challenges, and mitigation.https://link.springer.com/epdf/10.1186/s12936-022-04428-8?sharing_token=j1IEJyNzlssYKvPEXQUMl2_BpE1tBhCbnbw3BuzI2RNlXP-m0hrfx7V98IE2tswG36w6H_hnhQHELr4say76BfX1XojavUqmySLXrdsIwHUadbqx87zv4zDyzBVOXNG5dX8_fJiSDWIUJUulyeBNKQ6use_PQTQhqsnX0gmvNTU%3D

Gender Gap: A Qualitative Study of Women and Leadership Acquisition in Anesthesiology. https://journals.lww.com/anesthesia-analgesia/fulltext/2023/01000/gender_gap__a_qualitative_study_of_women_and.3.aspx

Political economy analysis of sub-national health sector planning and budgeting: A case study of three counties in Kenya.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001401

The ‘breakthrough’ obesity drugs that have stunned researchers. A class of drugs that quash hunger have shown striking results in trials and in practice. But can they help all people with obesity — and conquer weight stigma?https://www.nature.com/articles/d41586-022-04505-7

Predisposing and Precipitating Factors Associated With Delirium. A Systematic Review. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800112

Understanding maternity care providers’ use of data in Southern Tanzania.https://gh.bmj.com/content/8/1/e010937

Association between daily life walking speed and frailty measured by a smartphone application: a cross-sectional study. https://bmjopen.bmj.com/content/13/1/e065098

Acceptability and feasibility of tuberculosis and diabetes mellitus bidirectional screening and joint treatment services in Malawi: a cross-sectional study and a policy document review. https://bmjopen.bmj.com/content/13/1/e062009

Stress and coping strategies among parents of children with cancer at Tikur Anbessa Specialized Hospital paediatric oncology unit, Ethiopia: a phenomenological study.https://bmjopen.bmj.com/content/13/1/e065090

Human papillomavirus testing using existing nucleic acid testing platforms to screen women for cervical cancer: implementation studies from five sub-Saharan African countries. https://bmjopen.bmj.com/content/13/1/e065074

Potential benefit of extended dose schedules of human papillomavirus vaccination in the context of scarce resources and COVID-19 disruptions in low-income and middle-income countries: a mathematical modelling analysis.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00475-2/fulltext

Human papillomavirus vaccination strategies for accelerating action towards cervical cancer elimination. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00511-3/fulltext

Associations between punitive policies and legal barriers to consensual same-sex sexual acts and HIV among gay men and other men who have sex with men in sub-Saharan Africa: a multicountry, respondent-driven sampling survey.https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00336-8/fulltext

The financial architecture for global aid needs an urgent overhaul. Organisations cannot continue competing for increasingly scarce resources.https://www.ft.com/content/45dd2bd8-fa20-4b00-b220-a86a56e63549

The interconnected global emergencies of climate change, food security and health: a call to action by the Science for Africa Foundation [version 1; peer review: awaiting peer review]. https://openresearchafrica.org/articles/6-1

10 JAN 2023

Coronavirus variant XBB.1.5 rises in the United States — is it a global threat? Prevalence of a new subvariant of Omicron is increasing, but whether it will cause a big surge in infections or hospitalizations isn’t clear.https://www.nature.com/articles/d41586-023-00014-3

Association of alcohol consumption and frequency with loneliness: A cross-sectional study among Japanese workers during the COVID-19 pandemic.https://www.cell.com/heliyon/fulltext/S2405-8440(22)03221-2

Challenges faced in the cancer diagnosis and management—COVID-19 pandemic and beyond—Lessons for future. https://www.cell.com/heliyon/fulltext/S2405-8440(22)03379-5

Child Mortality in England During the First 2 Years of the COVID-19 Pandemic.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800144

SARS-CoV-2 Omicron Variant in Human Saliva Samples in Cell-Free Form.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800145

BNT162b2 Vaccine Effectiveness Against the SARS-CoV-2 Omicron Variant in Children Aged 5 to 11 Years.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800322

Asymptomatic screening for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) as an infection prevention measure in healthcare facilities: Challenges and considerations. https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/asymptomatic-screening-for-severe-acute-respiratory-coronavirus-virus-2-sarscov2-as-an-infection-prevention-measure-in-healthcare-facilities-challenges-and-considerations/5D9FF2904AD88CDBDA5CAFD29A965A69

Hospital admissions and need for mechanical ventilation in children with respiratory syncytial virus before and during the COVID-19 pandemic: a Danish nationwide cohort study. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(22)00371-6/fulltext

OTHER NEWS

Nature announces support for authors from over 70 countries to publish open access. Authors from low-income and lower-middle income countries to be able to publish for free in Nature and the Nature research journals https://group.springernature.com/gp/group/media/press-releases/nature-announces-support-for-authors-to-publish-open-access/23894926

Safety perception in the operating environment: The nurses’ perspective versus that of the surgeons. https://www.cell.com/heliyon/fulltext/S2405-8440(22)03964-0

Effectiveness of an educational module in improving knowledge, awareness and perception among pregnant women regarding the safe use of prenatal ultrasound.https://www.cell.com/heliyon/fulltext/S2405-8440(22)04061-0

An ethnozoological study of traditional medicinal animals and their products from Wolaita, Southern Ethiopia. https://www.cell.com/heliyon/fulltext/S2405-8440(22)04021-X

Pulse Oximeters and Violation of Federal Antidiscrimination Law.https://jamanetwork.com/journals/jama/fullarticle/2800468

Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality.https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800411

The Benefit-Risk Ratio of Late Preterm Antenatal Corticosteroids Could Be Unfavorable in Real-life Situations.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800321

The Benefit-Risk Ratio of Late Preterm Antenatal Corticosteroids Could Be Unfavorable in Real-life Situations—Reply.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800320

The Lancet Series on racism, xenophobia, discrimination, and health.https://www.thelancet.com/series/racism-xenophobia-discrimination-health

Not so FAST—Chest ultrasound underdiagnoses traumatic pneumothorax.https://journals.lww.com/jtrauma/Abstract/2022/01000/Not_so_FAST_Chest_ultrasound_underdiagnoses.8.aspx

11 JAN 2023

Why COVID’s XBB.1.5 ‘Kraken’ Variant Is So Contagious. A new variant of the virus that causes COVID has mutations that make it more transmissible, but vaccines are still likely to protect against severe disease.https://www.scientificamerican.com/article/why-covids-xbb-1-5-kraken-variant-is-so-contagious/

Paxlovid reduces serious risks from Omicron variants. https://www.nih.gov/news-events/nih-research-matters/paxlovid-reduces-serious-risks-omicron-variants?utm_source=dlvr.it&utm_medium=twitter

Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms.https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(22)00234-X?utm_medium=homepage

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD. https://www.cell.com/iscience/fulltext/S2589-0042(22)02056-9

Perceptions of Stress and Mood Associated With Listening to Music in Daily Life During the COVID-19 Lockdown.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800161

Outcomes Among Mechanically Ventilated Patients With Severe Pneumonia and Acute Hypoxemic Respiratory Failure From SARS-CoV-2 and Other Etiologies.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800158

Experience of the United Arab Emirates in the use of monoclonal antibody drug sotrovimab in high-risk vaccinated and unvaccinated patients with COVID-19: an observational cohort study. https://bmjopen.bmj.com/content/13/1/e066095

Breakthrough SARS-CoV-2 infections and prediction of moderate-to-severe outcomes during rituximab therapy in patients with rheumatic and musculoskeletal diseases in the UK: a single-centre cohort study.https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(23)00004-8/fulltext

Pfizer-BioNTech COVID-19 vaccine effectiveness against SARS-CoV-2 infection among long-term care facility staff with and without prior infection in New York City, January–June 2021. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac448/6982749?searchresult=1

Protection conferred by Delta and BA.1/BA.2 infection against BA.4/BA.5 infection and hospitalization: A Retrospective Cohort Study. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad003/6982684?searchresult=1

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis.https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025

OTHER NEWS

Enhancing cervical and breast cancer training in Africa with e-learning.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00499-5/fulltext

Got neck and back pain? Break up your work day with these 5 exercises for relief.https://www.npr.org/sections/health-shots/2023/01/05/1146374970/got-neck-and-back-pain-break-up-your-work-day-with-these-5-exercises-for-relief

Indigenous knowledge is key to sustainable food systems. Agricultural sciences have for too long ignored traditional and local knowledge about crop plants and how best to grow them. That must change if the world is to ensure future food security.https://www.nature.com/articles/d41586-023-00021-4

Colonoscopies save lives. Why did a trial suggest they might not?

A major clinical study raised questions about one of the most celebrated cancer-screening procedures available, but a close look at the data tells a different story.Overall, only 42% of people in the group that had been invited to get colonoscopies actually got one. If the compliance rate had been 100%, the researchers’ analysis showed, the test would have reduced cancer risk by 31% — from 1.22% to 0.84% — and it would have reduced the risk of death from colorectal cancer by 50% — from 0.3% to 0.15%. https://www.nature.com/articles/d41586-023-00020-5

Silence, escape and survival drive the persistence of HIV. Sophisticated experimental approaches reveal cellular and immune-system mechanisms that enable rare HIV-infected cells to persist for decades in people who are taking antiretroviral drugs.https://www.nature.com/articles/d41586-022-04492-9

A systematic scoping review of reflective writing in medical education.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03924-4

How do I deal with a racist patient? https://www.bmj.com/content/380/bmj.o2856

Are non-invasive or minimally invasive autopsy techniques for detecting cause of death in prenates, neonates and infants accurate? A systematic review of diagnostic test accuracy. https://bmjopen.bmj.com/content/13/1/e064774

Immunogenicity and safety of a 10-valent pneumococcal conjugate vaccine administered as a 2 + 1 schedule to healthy infants in The Gambia: a single-centre, double-blind, active-controlled, randomised, phase 3 trial.https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00734-4/fulltext

Technical meetings, conferences, and agency in global health. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00481-8/fulltext

Early-life stature, preschool cognitive development, schooling attainment, and cognitive functioning in adulthood: a prospective study in four birth cohorts. (includes South Africa) https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00448-X/fulltext

Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00463-6/fulltext

Risk Factors for Postoperative Bleeding Following Breast Cancer Surgery: A Nationwide Database Study of 477,108 Cases in Japan.https://link.springer.com/epdf/10.1007/s00268-022-06746-z?sharing_token=kFnpzdj-U_f9A2YCo2I1Wfe4RwlQNchNByi7wbcMAY56Unrsj9Ac99FkHAYSNdOhwPsX_4p4cTQDwYtEW46po8fCRhiLVFYYbbgv8UyB7ON_6K9RmU1IXLUuS-Wa7l3qA42920hgOFyajdHELPFl5pkUBwY5jCejXPcPkJoI94Q%3D

Does the Current Global Health Agenda Lack Vision?https://www.ghspjournal.org/content/early/2023/01/10/GHSP-D-22-00091

Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity.https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-060640/190443/Clinical-Practice-Guideline-for-the-Evaluation-and?autologincheck=redirected

Implementation of a Device Briefing Tool reduces interruptions in surgery: A nonrandomized controlled pilot trial. https://www.surgjournal.com/article/S0039-6060(22)01038-8/fulltext?dgcid=raven_jbs_aip_email#%20

Closed Incision Negative Pressure Therapy to Reduce Surgical Site Infection in High-Risk Gastrointestinal Surgery: A Randomized Controlled Trial. In this multi-institutional, randomized controlled trial among patients undergoing colorectal or hepatopancreatobiliary surgery, the difference in incisional SSI between ciNPT and conventional wound therapy was not statistically significant. Future trials should focus on patient populations undergoing the highest SSI risk procedures with more focus on specific procedure types. https://journals.lww.com/journalacs/Abstract/9900/Closed_Incision_Negative_Pressure_Therapy_to.457.aspx

12 JAN 2023

Swab the Throat as Well as the Nose? The Debate Over the Best Way to Test for SARS-CoV-2. https://jamanetwork.com/journals/jama/fullarticle/2800526

Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study. https://www.bmj.com/content/380/bmj-2022-072529

Vaccine incentives do not backfire — policymakers take note. Rigorously designed studies can dispel suspicions that offering cash for vaccines erodes trust, and help health-care providers to design effective immunization campaigns.https://www.nature.com/articles/d41586-023-00018-z

Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00025-6

Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00003-4

Audio Interview: Covid-19 Vaccines and New Viral Variants.https://www.nejm.org/doi/full/10.1056/NEJMe2300211?query=featured_home

Bivalent Covid-19 Vaccines — A Cautionary Tale.https://www.nejm.org/doi/full/10.1056/NEJMp2215780?query=featured_home

Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters.https://www.nejm.org/doi/full/10.1056/NEJMc2213948?query=featured_home

Antibody Response to Omicron BA.4–BA.5 Bivalent Booster.https://www.nejm.org/doi/full/10.1056/NEJMc2213907?query=featured_home

Immunogenicity and safety in healthy adults of full dose versus half doses of COVID-19 vaccine (ChAdOx1-S or BNT162b2) or full-dose CoronaVac administered as a booster dose after priming with CoronaVac: a randomised, observer-masked, controlled trial in Indonesia. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00800-3/fulltext

Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00512-0/fulltext

Twenty-Strain “Universal” mRNA Flu Vaccine Effective in Animal Studies.https://jamanetwork.com/journals/jama/fullarticle/2800207?guestAccessKey=97a80997-5277-4b40-8769-fced590d5974&utm_source=twitter&utm_medium=social_jama&utm_term=8590061856&utm_campaign=article_alert&linkId=196705805

OTHER NEWS

Polio eradication: Addressing the hurdles on the last mile.https://www.cell.com/cell/fulltext/S0092-8674(22)01534-3?utm_medium=homepage#%20

Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients. The SUSTAIN CSX Randomized Clinical Trial. High-dose sodium selenite was not effective in reducing the development of organ dysfunction and death in high-risk cardiac surgery patients. https://jamanetwork.com/journals/jamasurgery/fullarticle/2800335

The BMJ Appeal 2022-23: Cholera on the rise and how IFRC is working to fight it.https://www.bmj.com/content/380/bmj.o3007

Reverse mentoring—never stop learning. https://www.bmj.com/content/380/bmj.p75

Trends in inpatient and post-discharge mortality among young infants admitted to Kilifi County Hospital, Kenya: a retrospective cohort study.https://bmjopen.bmj.com/content/13/1/e067482

Effect of the introduction of screening for cancer precursor lesions on anal cancer incidence over time in people living with HIV: a nationwide cohort study.https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00368-X/fulltext

Equalizing the response to AIDS and other pandemics.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001370

3 JAN 2023

The COVID-19 pandemic in 2023: far from over.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00050-8/fulltext

Trial settles debate over best design for mRNA in COVID vaccines. The biggest defender of ‘unmodified’ mRNA for vaccines against infectious disease has a change of heart. https://www.nature.com/articles/d41586-023-00042-z

News at a glance: ‘Cherry-picked’ vaccine guidance, AI-written papers, and an apology for prisoner research. The latest in science and policy.https://www.science.org/content/article/news-glance-cherry-picked-vaccine-guidance-ai-written-papers-and-apology-prisoner

Cell Press Coronavirus Resource Hub. https://www.cell.com/COVID-19

Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19. A Randomized Clinical Trial. These findings do not support the use of fluvoxamine at this dose and duration in patients with mild to moderate COVID-19. https://jamanetwork.com/journals/jama/fullarticle/2800448

Lack of Benefit of Fluvoxamine for COVID-19.https://jamanetwork.com/journals/jama/fullarticle/2800449

COVID-19 Convalescent Plasma for the Treatment of Immunocompromised Patients: A Systematic Review and Meta-analysis.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800275

What do we know about covid-19 and children?https://www.bmj.com/content/380/bmj.p21

Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study. This nationwide study suggests that patients with mild covid-19 are at risk for a small number of health outcomes, most of which are resolved within a year from diagnosis. https://www.bmj.com/content/380/bmj-2022-072529

Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19. https://bmjopen.bmj.com/content/13/1/e066626

Immunogenicity and safety in healthy adults of full dose versus half doses of COVID-19 vaccine (ChAdOx1-S or BNT162b2) or full-dose CoronaVac administered as a booster dose after priming with CoronaVac: a randomised, observer-masked, controlled trial in Indonesia. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00800-3/fulltext

COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00552-1/fulltext

Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00512-0/fulltext

The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00612-0/fulltext

Safety Monitoring of Bivalent COVID-19 mRNA Vaccine Booster Doses Among Children Aged 5–11 Years — United States, October 12–January 1, 2023.https://www.cdc.gov/mmwr/volumes/72/wr/mm7202a5.htm?s_cid=mm7202a5_w

OTHER NEWS

Understanding resilience, self-reliance and increasing country voice: a clash of ideologies in global health. https://gh.bmj.com/content/8/1/e010895

Associations between HIV status and self-reported hypertension in a high HIV prevalence sub-Saharan African population: a cross-sectional study (Zimbabwe).https://bmjopen.bmj.com/content/13/1/e067327

Early initiation of antenatal care and its associated factors among pregnant women attending antenatal care at public health centres in Bahir Dar Zuria zone, Northwest Ethiopia, 2021: a cross-sectional study. https://bmjopen.bmj.com/content/13/1/e065169

Inferring the multiplicity of founder variants initiating HIV-1 infection: a systematic review and individual patient data meta-analysis.https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00327-5/fulltext

Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00616-8/fulltext

s41591-022-02136-z

16 JAN 2023

COVID-19 and other pandemics require a coherent response strategy.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02489-8/fulltext?utm_campaign=lancetcovid23&utm_content=234632370&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292

Long COVID: major findings, mechanisms and recommendations.https://www.nature.com/articles/s41579-022-00846-2

Repeat COVID-19 infections increase risk of organ failure, death. Researchers recommend masks, vaccines, vigilance to prevent reinfection.https://medicine.wustl.edu/news/repeat-covid-19-infections-increase-risk-of-organ-failure-death/

China’s COVID wave has probably peaked, model suggests

But a lack of data has obscured the true impact of the outbreak.https://www.nature.com/articles/d41586-023-00075-4

Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses. https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8?utm_medium=homepage

Evaluation of Inequities in Cancer Treatment Delay or Discontinuation Following SARS-CoV-2 Infection.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800399

Background rate estimations for thrombosis with thrombocytopaenia: challenges in evaluating rare safety signals following vaccination in real time during a pandemic.https://bmjopen.bmj.com/content/13/1/e063645

The relationship between the sources of confidence in overcoming COVID-19 and the improvement of medical students’ professional identity: mediation by medical students’ attention to COVID-19.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03994-4

Immunogenicity and safety in healthy adults of full dose versus half doses of COVID-19 vaccine (ChAdOx1-S or BNT162b2) or full-dose CoronaVac administered as a booster dose after priming with CoronaVac: a randomised, observer-masked, controlled trial in Indonesia, https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00800-3/fulltext

COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00552-1/fulltext

Comparative outcomes of extracorporeal membrane oxygenation for COVID-19 delivered in experienced European centres during successive SARS-CoV-2 variant outbreaks (ECMO-SURGES): an international, multicentre, retrospective cohort study.https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00438-6/fulltext

OTHER NEWS

The Specialist Anesthesiology Workforce in East, Central, and Southern Africa: A Cross-Sectional Study. https://journals.lww.com/anesthesia-analgesia/Fulltext/2023/02000/The_Specialist_Anesthesiology_Workforce_in_East,.8.aspx

Early initiation of breastfeeding is inversely associated with public and private c-sections in 73 lower- and middle-income countries.https://www.nature.com/articles/s41598-022-25564-w

SHIFTING POWER IN GLOBAL HEALTH. Decolonising Discourses — Series Synthesis. SUMMARY OF UNITED NATIONS UNIVERSITY, DEVELOPMENT REIMAGINED, AND WILTON PARK VIRTUAL DIALOGUE SERIES.https://drive.google.com/file/d/1C9Jnzew7-E4kmFZVTAY5nbURjWUuEz7g/view

Surgeon Well-Being. Resources to foster well-being, resilience, and work-life integration at every stage of your career. https://www.facs.org/for-medical-professionals/professional-growth-and-wellness/surgeon-wellbeing/

Accuracy of ultrasound-guided targeted fine-needle aspiration in assessing nodal response in node-positive breast cancer after neoadjuvant chemotherapy: prospective feasibility study. https://academic.oup.com/bjs/article/109/12/1194/6677263?login=false

Saving Children’s Lives by Improving Pediatric Readiness for Emergency Care. The weighted Pediatric Readiness Score (wPRS) serves as a measure of adherence to 6 domains of pediatric emergency care: coordination of care, physician and nurse staffing, quality improvement, patient safety, policies and procedures, and equipment and supplies.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800408?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=011323#.Y8GST64sHPU.twitter

Emergency Department Pediatric Readiness and Short-term and Long-term Mortality Among Children Receiving Emergency Care.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800400

Advances in the clinical management of high-risk Wilms tumors.https://pubmed.ncbi.nlm.nih.gov/36625399/#affiliation-1

Financing global health security: estimating the costs of pandemic preparedness in Global Fund eligible countries. https://gh.bmj.com/content/8/1/e008960

Risk of Esophageal and Gastric Cancer After Bariatric Surgery. The findings of this study suggest that bariatric surgery can be performed as treatment for severe obesity without increasing the risk of esophageal and gastric cancer. https://jamanetwork.com/journals/jamasurgery/fullarticle/2800334?guestAccessKey=bee7facb-bd3d-426d-9231-da7bc4d69e73&utm_source=twitter&utm_medium=social_jamasurg&utm_term=8601115648&utm_campaign=article_alert&linkId=196847801

Close to one billion people globally are served by health-care facilities with no electricity access or with unreliable electricity. Close to 1 billion people in low- and lower-middle income countries are served by health-care facilities with unreliable electricity supply or with no electricity access at all, according to a new report from the World Health Organization (WHO), the World Bank, the International Renewable Energy Agency (IRENA), and Sustainable Energy for All (SEforAll). https://www.who.int/news/item/14-01-2023-close-to-one-billion-people-globally-are-served-by-health-care-facilities-with-no-electricity-access-or-with-unreliable-electricity

Gene Drives Could Fight Malaria and Other Global Killers but Might Have Unintended Consequences. A new technology could wipe out whole species. Is it a magic bullet or a genetic atom bomb? https://www.scientificamerican.com/article/gene-drives-could-fight-malaria-and-other-global-killers-but-might-have-unintended-consequences/

Spatiotemporal dynamics of malaria in Zanzibar, 2015–2020.https://gh.bmj.com/content/8/1/e009566

Minor injuries: laceration repairs. https://www.bmj.com/content/380/bmj-2021-067573

Risk factors of multidrug resistant tuberculosis among patients with tuberculosis at selected multidrug resistance treatment initiative centres in southern Ethiopia: a case-control study. https://bmjopen.bmj.com/content/13/1/e061836

Prevalence of early postnatal care services usage and associated factors among postnatal women of Wolkite town, Gurage zone, Southern Ethiopia: a community-based cross-sectional study. https://bmjopen.bmj.com/content/13/1/e061326

The educational paradigm shift—a phenomenographic study of medical teachers’ experiences of practices.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04013-w

Understanding the barriers and enablers for postgraduate medical trainees becoming simulation educators: a qualitative study. Mbarara University of Science and Technology (MUST) in Uganda. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03995-3

Advanced neonatal procedural skills: a simulation-based workshop: impact and skill decay. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04000-1

Can educational video resources improve learning when used to augment traditional teaching of clinical examination? A randomized control trial of novice medical students. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03974-8

Application and curative effect of laparoscopic purse-string sutures in the treatment of adult acute complicated appendicitis. Compared with the control group, the postoperative hospital length of stay, duration of antibiotic treatment, the recovery time of peripheral white blood cell and neutrophil counts and the incidence of postoperative complications in the observation group were significantly decreased (P < 0.05). https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-022-01884-6

Evaluating post-treatment Loa loa microfilarial densities to classify serious adverse events caused by ivermectin: a retrospective analysis.https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00331-7/fulltext

Predicted effects of the introduction of long-acting injectable cabotegravir pre-exposure prophylaxis in sub-Saharan Africa: a modelling study. https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00365-4/fulltext

Cataracts. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01839-6/fulltext?utm_campaign=seminar&utm_content=234681451&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292

A four minute guide to the rudiments of health and healthcare for those responsible for maintaining health systems. https://www.bmj.com/content/380/bmj.p107

The medicinal value of tea drinking in the management of COVID-19.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00175-5

SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron. https://www.cell.com/iscience/fulltext/S2589-0042(23)00072-X

The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling. https://www.cell.com/iscience/fulltext/S2589-0042(23)00052-4

Acute pancreatitis following COVID-19 vaccine: A case report and brief literature review. Therefore, to better diagnosis and prevention of long-term complications, it is necessary to measuring the lipase or amylase in patients that received COVID-19 vaccine if abdominal pain was occurred. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00121-4

Bionics design of affinity peptide inhibitors for SARS-CoV-2 RBD to block SARS-CoV-2 RBD-ACE2 interactions. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00097-X

COVID-19 outbreak after 100 days without community transmission: Epidemiological analysis of factors associated with death. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00148-2

“Pneumomediastinum: A marker of severity in Covid-19 disease”.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00188-3

The medicinal value of tea drinking in the management of COVID-19.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00175-5

BNT162b2 effectiveness against Delta and Omicron variants of SARS-CoV-2 in adolescents aged 12-17 years, by dosing interval and duration.https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad006/6988115

OTHER NEWS

Understanding resilience, self-reliance and increasing country voice: a clash of ideologies in global health. https://gh.bmj.com/content/8/1/e010895

Gender Gap: A Qualitative Study of Women and Leadership Acquisition in Anesthesiology. https://journals.lww.com/anesthesia-analgesia/Abstract/2023/01000/Gender_Gap__A_Qualitative_Study_of_Women_and.3.aspx

Maternal and perinatal outcomes of failed prostaglandin induction of labour: A retrospective cohort study. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00262-1

Relation between students’ personality traits and their preferred teaching methods: Students at the university of Ghana and the Huzhou Normal University.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00218-9

Determinants of safe food handling practice among food handlers in food establishments, Yeka sub city, Addis Ababa, Ethiopia.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00184-6

Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac498/6986913

The origins and risk factors for serotype-2 vaccine-derived poliovirus (VDPV2) emergences in Africa during 2016-2019. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad004/6984902

Measuring the global response to antimicrobial resistance, 2020–21: a systematic governance analysis of 114 countries. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00796-4/fulltext

How to write a book chapter. https://www.americanjournalofsurgery.com/article/S0002-9610(23)00016-8/fulltext

Consumption of Fast Food Linked to Potentially Deadly Liver Disease. https://scitechdaily.com/consumption-of-fast-food-linked-to-potentially-deadly-liver-disease/

17 Jan 2023

The medicinal value of tea drinking in the management of COVID-19.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00175-5

SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron. https://www.cell.com/iscience/fulltext/S2589-0042(23)00072-X

The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling. https://www.cell.com/iscience/fulltext/S2589-0042(23)00052-4

Bionics design of affinity peptide inhibitors for SARS-CoV-2 RBD to block SARS-CoV-2 RBD-ACE2 interactions. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00097-X

COVID-19 outbreak after 100 days without community transmission: Epidemiological analysis of factors associated with death. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00148-2

“Pneumomediastinum: A marker of severity in Covid-19 disease”.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00188-3

The medicinal value of tea drinking in the management of COVID-19.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00175-5

OTHER NEWS

Understanding resilience, self-reliance and increasing country voice: a clash of ideologies in global health. https://gh.bmj.com/content/8/1/e010895

Maternal and perinatal outcomes of failed prostaglandin induction of labour: A retrospective cohort study. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00262-1

Determinants of safe food handling practice among food handlers in food establishments, Yeka sub city, Addis Ababa, Ethiopia.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00184-6

Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection. https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac498/6986913

How to write a book chapter. https://www.americanjournalofsurgery.com/article/S0002-9610(23)00016-8/fulltext

Consumption of Fast Food Linked to Potentially Deadly Liver Disease. A new study from Keck Medicine of USC found that fast food consumption is associated with nonalcoholic fatty liver disease, a serious condition in which fat builds up in the liver. The study revealed that people with obesity or diabetes who consume 20% or more of their daily calories from fast food have severely elevated levels of fat in their liver compared to those who consume less or no fast food. The general population also has moderate increases of liver fat when one-fifth or more of their diet is fast food. https://scitechdaily.com/consumption-of-fast-food-linked-to-potentially-deadly-liver-disease/

18 Jan 2023

COVID-19 vaccine acceptance in sub-Saharan African countries: A systematic review and meta-analysis. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00244-X

Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis (includes Kenya, South Africa, & Uganda). https://gh.bmj.com/content/8/1/e009495

How your first brush with COVID warps your immunity. The immune system responds more strongly to the strain of a virus that it first met, weakening response to other strains. Can this ‘imprinting’ be overcome? https://www.nature.com/articles/d41586-023-00086-1

Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00252-9

SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron. https://www.cell.com/iscience/fulltext/S2589-0042(23)00072-X

Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00049-9

Prevalent and immunodominant CD8 T-cell epitopes are conserved in SARS-CoV-2 variants. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00006-2

Pandemic preparedness and response: beyond the Access to COVID-19 Tools Accelerator. https://gh.bmj.com/content/8/1/e010615

Implementation of data triangulation and dashboard development for COVID-19 vaccine adverse event following immunisation (AEFI) data in Nigeria.https://gh.bmj.com/content/8/1/e011006

Better recognition for research participants: what society should learn from covid-19.https://www.bmj.com/content/380/bmj-2022-071178

Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study. COVID-19 in pregnancy, during the first 6 months of omicron as the variant of concern, was associated with increased risk of severe maternal morbidity and mortality, especially among symptomatic and unvaccinated women. Women with complete or boosted vaccine doses had reduced risk for severe symptoms, complications, and death. Vaccination coverage among pregnant women remains a priority. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02467-9/fulltext

OTHER NEWS

Postgraduate Surgical Education in East, Central, and Southern Africa: A Needs Assessment Survey. This needs assessment identified educational needs and priorities of COSECSA surgeons. Our study will serve as a foundation for interventions aimed at further improving graduate surgical education and ultimately patient care in the region. https://journals.lww.com/journalacs/Abstract/2023/02000/Postgraduate_Surgical_Education_in_East,_Central,.19.aspx

Are Gas Stoves Bad for Our Health? Evidence is building that fumes from gas stoves can aggravate lung ailments. https://www.scientificamerican.com/article/are-gas-stoves-bad-for-our-health/

Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure. The TRANSFORM-HF Randomized Clinical Trial. Among patients discharged after hospitalization for heart failure, torsemide compared with furosemide did not result in a significant difference in all-cause mortality over 12 months; however, interpretation of these findings is limited by loss to follow-up and participant crossover and nonadherence. https://jamanetwork.com/journals/jama/fullarticle/2800428

Longitudinal Developmental Outcomes of Infants and Toddlers With Traumatic Brain Injury. The findings of this study suggest that children with severe TBI should receive early childhood intervention, while children with mild TBI should receive routine developmental surveillance.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800486

Unexpected Successes. Can We Identify Positive Deviance in Surgery? However, such a framework may overlook lessons and insights that may be available from cases without complications, especially cases with positive outcomes despite being high risk for postoperative complications. These cases with unexpected positive outcomes have been referred to as positive deviants. The concept of positive deviance is being increasingly applied to quality improvement within healthcare organizations, but has rarely been used in the context of M&M. https://journals.lww.com/aosopen/Fulltext/2023/03000/Unexpected_Successes__Can_We_Identify_Positive.3.aspx?context=LatestArticles

Surgical Site Infection Prevention. A Review. Avoiding razors for hair removal, maintaining normothermia, use of chlorhexidine gluconate plus alcohol–based skin preparation agents, decolonization with intranasal antistaphylococcal agents and antistaphylococcal skin antiseptics for high-risk procedures, controlling for perioperative glucose concentrations, and using negative pressure wound therapy can reduce the rate of surgical site infections. https://jamanetwork.com/journals/jama/fullarticle/2800424

WHO Report: Cholera Resurgent in 2022 After Years of Decline.https://jamanetwork.com/journals/jama/fullarticle/2800419

Increasing Antimicrobial Resistance Poses Global Threat, WHO Says.https://jamanetwork.com/journals/jama/fullarticle/2800418

Acceptance and use of the distance education systems of Turkish medical educators during COVID-19 pandemic: an analysis of contextual factors with the UTAUT2. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04024-7

Employability in health professional education: a scoping review.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03913-7

The creation of the Global Scales for Early Development (GSED) for children aged 0–3 years: combining subject matter expert judgements with big data.https://gh.bmj.com/content/8/1/e009827

Qualitative study of practices and attitudes towards physical activity among prediabetic men and women in urban and rural Malawi.https://bmjopen.bmj.com/content/13/1/e058261

2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial. 2 days of postoperative intravenous antibiotics for complex appendicitis is non-inferior to 5 days in terms of infectious complications and mortality within 90 days, based on a non-inferiority margin of 7·5%. These findings apply to laparoscopic appendicectomy conducted in a well resourced health-care setting. Adopting this strategy will reduce adverse effects of antibiotics and length of hospital stay. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02588-0/fulltext

19 Jan 2023

Audio Interview: Weighing the Protective Value of Covid-19 Infection.https://www.nejm.org/doi/full/10.1056/NEJMe2300654?query=featured_home

Bivalent Omicron BA.1–Adapted BNT162b2 Booster in Adults Older than 55 Years.https://www.nejm.org/doi/full/10.1056/NEJMoa2213082?query=featured_home

Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1. https://www.nejm.org/doi/full/10.1056/NEJMc2214314?query=featured_home

Protection against Reinfection with the Omicron BA.2.75 Subvariant.https://www.nejm.org/doi/full/10.1056/NEJMc2214114?query=featured_home

NIH Pilots Telehealth Program for COVID-19.https://jamanetwork.com/journals/jama/fullarticle/2800766

Patients With Mild COVID-19 at Risk of Some Post–COVID-19 Condition Symptoms.https://jamanetwork.com/journals/jama/fullarticle/2800762

Persistent COVID-19 Symptoms at 6 Months After Onset and the Role of Vaccination Before or After SARS-CoV-2 Infection.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800554

How are covid-19 symptoms changing? https://www.bmj.com/content/380/bmj.p3

Better recognition for research participants: what society should learn from covid-19.https://www.bmj.com/content/380/bmj-2022-071178

Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00801-5/fulltext

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2.https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00337-8/fulltext

OTHER NEWS

Sitting all day can be deadly. 5-minute walks can offset harms.https://www.npr.org/sections/health-shots/2023/01/12/1148503294/sitting-all-day-can-be-deadly-5-minute-walks-can-offset-harms

Multimillion-dollar trade in paper authorships alarms publishers. Journals have begun retracting publications with suspicious links to sites trading in author positions.Research-integrity sleuths have uncovered hundreds of online advertisements that offer the chance to buy authorship on research papers to be published in reputable journals. https://www.nature.com/articles/d41586-023-00062-9

ChatGPT listed as author on research papers: many scientists disapprove. At least four articles credit the AI tool as a co-author, as publishers scramble to regulate its use. ChatGPT is a large language model (LLM), which generates convincing sentences by mimicking the statistical patterns of language in a huge database of text collated from the Internet. The bot is already disrupting sectors including academia: in particular, it is raising questions about the future of university essays and research production. https://www.nature.com/articles/d41586-023-00107-z

Allergy: Mechanistic insights into new methods of prevention and therapy.https://www.science.org/doi/10.1126/scitranslmed.add2563

To reduce ‘reputational bias,’ NIH may revamp how grant proposals are scored. Proposed changes to peer review seek to minimize influence of applicant’s resume and workplace. https://www.science.org/content/article/reduce-reputational-bias-nih-may-revamp-how-grant-proposals-are-scored

Single incision laparoscopic appendectomy with surgical-glove port is cost-effective and reliable in complicated acute appendicitis: A casecontrol multicenter study in Colombia. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00179-2

Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture. In patients with extremity fractures that had been treated operatively or with any pelvic or acetabular fracture, thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin in preventing death and was associated with low incidences of deep-vein thrombosis and pulmonary embolism and low 90-day mortality. https://www.nejm.org/doi/full/10.1056/NEJMoa2205973?query=featured_home

AAP Recommends Immediate, Intensive Treatment for Child Obesity.https://jamanetwork.com/journals/jama/fullarticle/2800765

Defining Posttraumatic Sepsis for Population-Level Research.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800552

Whole-Blood Resuscitation Following Traumatic Injury and Hemorrhagic Shock—Should It Be Standard Care?https://jamanetwork.com/journals/jamasurgery/fullarticle/2800605

Global health, sexual and reproductive health and rights, and gender: square pegs, round holes. https://gh.bmj.com/content/8/1/e011710

Gestational age at birth and cognitive outcomes in adolescence: population based full sibling cohort study. https://www.bmj.com/content/380/bmj-2022-072779

Health and wellbeing of older people in LMICs: a call for research-informed decision making. https://www.sciencedirect.com/science/article/pii/S2214109X22005460

Postoperative Overtriage to an Intensive Care Unit Is Associated With Low Value of Care. https://journals.lww.com/annalsofsurgery/Abstract/2023/02000/Postoperative_Overtriage_to_an_Intensive_Care_Unit.1.aspx

20 Jan 2023

Persistent COVID-19 Symptoms at 6 Months After Onset and the Role of Vaccination Before or After SARS-CoV-2 Infection. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800554

Daily briefing: mRNA vaccine for RSV shows promise. Moderna reports that its vaccine for respiratory syncytial virus is effective in older adults. Plus, how your first brush with COVID changes your immunity and the first-ever transgenic ants glow to show brain activity. https://www.nature.com/articles/d41586-023-00126-w

Omicron Mutations Increase Interdomain Interactions and Reduce Epitope Exposure in the SARS-CoV-2 Spike. https://www.cell.com/iscience/fulltext/S2589-0042(23)00058-5

Experiential student study groups: perspectives on medical education in the post-COVID-19 period. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04006-9

Is there a role for RDTs as we live with COVID-19? An assessment of different strategies. https://gh.bmj.com/content/8/1/e010690

OTHER NEWS

Largest-ever study of journal editors highlights ‘self-publication’ and gender gap. Analysis shows that some researchers publish a considerable proportion of their own work in journals they edit. https://www.nature.com/articles/d41586-023-00129-7

Study links viral infections to Alzheimer’s, Parkinson’s—with many caveats. Flu and other viruses are associated with six brain diseases, but aren’t proven culprits.https://www.science.org/content/article/study-links-viral-infections-alzheimer-s-parkinson-s-many-caveats

The Health Risks of Gas Stoves Explained. Gas stoves produce emissions that can harm human health and the environment. Experts answer questions about the dangers and how to limit them. https://www.scientificamerican.com/article/the-health-risks-of-gas-stoves-explained/

An Old TB Vaccine Might Help Stave Off Diabetes, Cancer Alzheimer’s, and More . The BCG vaccine might assist in preventing a range of major diseases. https://www.scientificamerican.com/article/an-old-tb-vaccine-might-help-stave-off-diabetes-cancer-alzheimers-and-more/

Challenges of sanitation in developing counties – Evidenced from a study of fourteen towns, Ethiopia. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00139-1

Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00299-2

Management of Latent Tuberculosis Infection.https://jamanetwork.com/journals/jama/fullarticle/2800774

New Approaches Needed to Improve Prevention of Cardiovascular Disease.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800618

Long-term Trajectories of Physical Function Decline in Women With and Without Cancer. https://jamanetwork.com/journals/jamaoncology/fullarticle/2800753

Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers.https://jamanetwork.com/journals/jamasurgery/fullarticle/2800598

Developing a CPD model for Eswatini—a participatory action research study.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04016-7

Using Kane’s framework to build an assessment tool for undergraduate medical student’s clinical competency with point of care ultrasound.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04030-9

A survey of clinical empathy training at UK medical schools.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03993-5

Quality of maternal healthcare and travel time influence birthing service utilisation in Ghanaian health facilities: a geographical analysis of routine health data.https://bmjopen.bmj.com/content/13/1/e066792

One Health: a call for ecological equity.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00090-9/fulltext

Closing the gaps in tuberculosis detection—considerations for policy makers.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(23)00008-6/fulltext

23 Jan 2023

COVID-19 vaccines versus pediatric hospitalization. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00028-9

Evaluation of an automated CRISPR-based diagnostic tool for rapid detection of COVID-19. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00397-3

Mental health and psychosocial problems among laboratory technicians in response to the COVID-19 pandemic in Hebei, China.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00297-9

Antibody titer levels and the effect on subsequent SARS-CoV-2 infection in a large US-based cohort. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00310-9

Perceptions towards online learning among medical students during the COVID-19 pandemic. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00326-2

Incidence of Respiratory Syncytial Virus Infection in Older Adults Before and During the COVID-19 Pandemic.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800696

Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study. https://bmjopen.bmj.com/content/13/1/e069194

Effects of the COVID-19 pandemic on essential health and nutrition service utilisations in Ghana: interrupted time-series analyses from 2016 to 2020.https://bmjopen.bmj.com/content/13/1/e061608

OTHER NEWS

International Neurosurgery: The Role for Collaboration.https://zenodo.org/record/7500584#.Y8xiWi-B3PA

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.https://www.nejm.org/doi/full/10.1056/NEJMoa2212663

Association between Antibiotic Redosing Prior to Incision and Risk of Incisional Site Infection in Children with Appendicitis.https://journals.lww.com/annalsofsurgery/Abstract/9900/Association_between_Antibiotic_Redosing_Prior_to.306.aspx

Affordances as experienced by university faculties during and after the sudden transition to online teaching. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00366-3

The role of emotional intelligence in EFL learners’ academic literacy development.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00317-1

Characteristics of exceptionally good Doctors—A survey of public adults.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00322-5

Health and Economic Outcomes Associated With Musculoskeletal Disorders Attributable to High Body Mass Index in 192 Countries and Territories in 2019.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800695

The Role of Prenatal Psychosocial Stress in the Associations of a Proinflammatory Diet in Pregnancy With Child Adiposity and Growth Trajectories.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800693

Association Between Early Return to School Following Acute Concussion and Symptom Burden at 2 Weeks Postinjury.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800690

The uncomfortable truths about visa discrimination and global health conferences.https://www.bmj.com/content/380/bmj.p78

24 Jan 2023

Targeting intracellular Neu1 for Coronavirus Infection Treatment.https://www.cell.com/iscience/fulltext/S2589-0042(23)00114-1

Omicron Mutations Increase Interdomain Interactions and Reduce Epitope Exposure in the SARS-CoV-2 Spike. https://www.cell.com/iscience/fulltext/S2589-0042(23)00058-5

CO RADS grade of HRCT Thorax and RT PCR testing for the diagnosis of coronavirus disease 2019 (COVID 19): A descriptive hospital based study of asymptomatic planned surgery cases. https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2023;volume=22;issue=1;spage=40;epage=44;aulast=Ghosh

Association of vitamin D with the severity of disease and mortality in COVID-19: Prospective study in central India. https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2023;volume=22;issue=1;spage=117;epage=123;aulast=Rathod

Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800703

Development of COVID-19 Vaccines—An Unanticipated Moon Shot Achieved at Warp Speed. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800713

COVID-19 Vaccines in Young Children—Reassuring Evidence for Parents.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800744

Assessment of Efficacy and Safety of mRNA COVID-19 Vaccines in Children Aged 5 to 11 Years. A Systematic Review and Meta-analysis.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800743

COVID-19 Vaccination During Pregnancy.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800741

COVID-19 Vaccination During Pregnancy—Reply.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800740

Students’ perception of asynchronous versus synchronous distance learning during COVID-19 pandemic in a medical college, southwestern region of Saudi Arabia.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04034-5

Improving the response to future pandemics requires an improved understanding of the role played by institutions, politics, organization, and governance.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001501

OTHER NEWS

Adult HIV-1 incidence across 15 high-burden countries in sub-Saharan Africa from 2015 to 2019: a pooled analysis of nationally representative data.https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00328-9/fulltext

Massive health-record review links viral illnesses to brain disease

Study ties common viruses such as flu to Alzheimer’s and other conditions — but the analysis has limitations, researchers warn. https://www.nature.com/articles/d41586-023-00181-3

Impact of workplace bullying, and burnout on job satisfaction among Bangladeshi nurses: A cross-sectional study. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00369-9

Statistics: Conditional Power. How Likely Is Trial Success? This JAMA Guide to Statistics and Methods article examines conditional power, calculated while a trial is ongoing and based on both the currently observed data and an assumed treatment effect for future patients. https://jamanetwork.com/journals/jama/fullarticle/2800892

Comparison between intermittent epidural bolus of levobupivacaine 0.125% and ropivacaine 0.2% with fentanyl as adjuvant for combined spinal epidural technique in labor analgesia: A double blinded prospective study.https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2023;volume=22;issue=1;spage=88;epage=93;aulast=Thammaiah

Is There Enough Choline for Children in Food Aid?https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800737

Teaching to transform surgical culture: an educational programme and thematic analysis in a general surgery department.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03941-3

Linkages between malaria and malnutrition in co-endemic regions of India.https://gh.bmj.com/content/8/1/e010781?rss=1

Covid-19: Vaccination plus infection offers best protection, finds study led by WHO.https://www.bmj.com/content/380/bmj.p171

Dementia risk after major elective surgery based on the route of anaesthesia: a propensity score-matched population-based cohort study.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00457-6/fulltext

25 Jan 2023

Reasons for reductions in routine childhood immunisation uptake during the COVID-19 pandemic in low- and middle-income countries: A systematic review.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001415

The next worrisome coronavirus variant could come from China — will it get detected? Genomic surveillance is crucial for tracking the next ‘variant of concern’, but many countries are winding back their monitoring. https://www.nature.com/articles/d41586-023-00112-2

Dynamic Activity in cis-Regulatory Elements of Leukocytes Identifies Transcription Factor Activation and Stratifies COVID-19 Severity in ICU Patients.https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00027-7

Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(23)00007-4/fulltext

Effect of vaccine booster, vaccine type, and hybrid immunity on humoral and cellular immunity against SARS-CoV-2 ancestral strain and Omicron variant sublineages BA.2 and BA.5 among older adults with comorbidities: a cross sectional study.https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00011-7/fulltext

ASPPH COVID-19 STORYTELLING PROJECT: HOW SCHOOLS AND PROGRAMS MADE AN IMPACT DURING THE PANDEMIC. Explore an array of compelling stories of how academic public health institutions & all ASPPH members worked within their universities, communities, regions and states to keep the public safe during the COVID-19 pandemic. https://covid19storytelling.aspph.org

OTHER NEWS

Association Between Parental Education and Simultaneous Malnutrition Among Parents and Children in 45 Low- and Middle-Income Countries. In this study, maternal education and paternal education were independently associated with DBM, and the associations differed by DBM subtypes. These findings suggest that the different risks of malnutrition faced by households with various levels of education should thus be considered in policy evaluation. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800722

How antidepressants help bacteria resist antibiotics. A laboratory study unravels ways non-antibiotic drugs can contribute to drug resistance. https://www.nature.com/articles/d41586-023-00186-y

Don’t wait for an Ebola outbreak to vaccinate people against it. The Ebola outbreak in Uganda was a wake-up call. We need preventive vaccination.https://www.nature.com/articles/d41586-023-00184-0

Self-publishing editors, and more — this week’s best science graphics. Three charts from the world of research, selected by Nature editors.https://www.nature.com/articles/d41586-023-00200-3

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use. As researchers dive into the brave new world of advanced AI chatbots, publishers need to acknowledge their legitimate uses and lay down clear guidelines to avoid abuse. https://www.nature.com/articles/d41586-023-00191-1

Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial. https://www.bmj.com/content/380/bmj-2022-072313

Efficacy of pyriproxyfen-pyrethroid long-lasting insecticidal nets (LLINs) and chlorfenapyr-pyrethroid LLINs compared with pyrethroid-only LLINs for malaria control in Benin: a cluster-randomised, superiority trial.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02319-4/fulltext

The (il)legitimacy of death as an option.https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(23)00011-1/fulltext

Managing Complications Part 1: Yourself. Introduction: The Second Victim Syndrome.https://www.vumc.org/global-surgical-atlas/sites/default/files/public_files/PDF/Managing%20Complications%20Part%201-%20Yourself.pdf

Asthma management and control in children, adolescents, and adults in 25 countries: a Global Asthma Network Phase I cross-sectional study.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00506-X/fulltext

26 Jan 2023

Daily briefing: Common viral infections are linked to neurodegenerative conditions. Huge health-record review links viral illnesses to elevated risk of brain disease. Plus, Earth’s inner core might have slowed its spin and many of Australia’s researchers are miserable at work. https://www.nature.com/articles/d41586-023-00209-8

What’s next for COVID-19 vaccines? Scientists and regulators chart a course amid uncertainty. FDA panel will discuss switch to an annual booster in the fall, akin to flu vaccination strategy. https://www.science.org/content/article/what-s-next-covid-19-vaccines-scientists-and-regulators-chart-course-amid-uncertainty

Covid Vaccines — Playing the Long Game.https://www.nejm.org/doi/full/10.1056/NEJMp2300222?query=featured_home

Effectiveness of Bivalent Boosters against Severe Omicron Infection. https://www.nejm.org/doi/full/10.1056/NEJMc2215471?query=featured_home

Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine. https://www.nejm.org/doi/full/10.1056/NEJMc2214916?query=featured_home

Immunogenicity of a Fourth Homologous Dose of NVX-CoV2373.https://www.nejm.org/doi/full/10.1056/NEJMc2215509?query=featured_home

Large Cohort Study Finds Possible Association Between Postural Orthostatic Tachycardia Syndrome and COVID-19 Vaccination but Far Stronger Link With SARS-CoV-2 Infection. https://jamanetwork.com/journals/jama/fullarticle/2800964

NIH Funds Research on Severe COVID-19–Related Illness in Children.https://jamanetwork.com/journals/jama/fullarticle/2800970

Unreported SARS-CoV-2 Home Testing and Test Positivity.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800732

OTHER NEWS

Better Patient Care Calls for a ‘Platinum Rule’ to Replace the Golden One. A new principle in medicine focuses on understanding patients’ values, not assuming they share your own. https://www.scientificamerican.com/article/better-patient-care-calls-for-a-platinum-rule-to-replace-the-golden-one/

Antiretroviral Therapy and Adverse Pregnancy Outcomes in People Living with HIV.https://www.nejm.org/doi/full/10.1056/NEJMra2212877?query=featured_home

Plan Calls for Global Collaboration to Address Child Undernutrition.https://jamanetwork.com/journals/jama/fullarticle/2800972

Anesthesiologists Are Integral to Value-Based Surgical Care Reform.https://jamanetwork.com/journals/jamasurgery/fullarticle/2800532

Ticket to perform: an explorative study of trainees’ engagement in and transfer of surgical training. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04048-z

A Modified Medical Education Research Study Quality Instrument (MMERSQI) developed by Delphi consensus.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04033-6

Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study.https://www.bmj.com/content/380/bmj-2022-072691

The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02469-2/fulltext

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00793-9/fulltext

30 Jan 2023

Statement on the fourteenth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic.https://www.who.int/news/item/30-01-2023-statement-on-the-fourteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic

Peter Hotez on Patent-Free Vaccines—and Texas, Tito’s, and Twitter. Amid a global vaccine race that led to colossal windfalls for Big Pharma and left poor nations behind, Hotez’s team created a patent-free COVID vaccine that has already begun filling vaccine gaps around the world. And a new bivalent booster is in the works.https://globalhealthnow.org/2023-01/peter-hotez-patent-free-vaccines-and-texas-titos-and-twitter

CRISPR screening reveals a requirement for ribosome recycling in efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication.https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00087-6

Review on the use of eLearning in teacher education during the corona virus disease (COVID-19) pandemic in Africa. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00515-7

The influence of intrinsic and extrinsic motivational factors on e-WOM (Electronic word-of-mouth) behaviour: The role of psychological impact during the time of COVID-19 crisis. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00477-2

Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00530-3

Effectiveness of facial palsy protocol among patient with mucormycosis following COVID-19: A case study. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00416-4

Peer Review in a General Medical Research Journal Before and During the COVID-19 Pandemic. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800858

Comparison of Preprint Postings of Randomized Clinical Trials on COVID-19 and Corresponding Published Journal Articles. A Systematic Review.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800857

Realising the right to participate in pandemic prevention, preparedness and response and beyond. https://gh.bmj.com/content/8/1/e011689

Capacity building at points of entry during COVID-19 pandemic: harmonising training curriculum for Economic Community of West African States.https://gh.bmj.com/content/8/1/e010892

Covid-19: JCVI recommends autumn vaccine booster for the most vulnerable.https://www.bmj.com/content/380/bmj.p204

Precarious work and the covid-19 pandemic: the need for a gender equality focus.https://www.bmj.com/content/380/bmj-2022-072872

What do we know about the adaptive immune response to covid-19?https://www.bmj.com/content/380/bmj.p19

Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalised with COVID-19 (COVASP): a pragmatic, cluster-randomised, non-inferiority trial. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00832-5/fulltext

Managing Complications Part 2: The Patient and Family. Dealing with adverse outcomes, continued- “Managing Complications Part 2: Patient and Family.” A very important skill for a surgeon to have. https://www.vumc.org/global-surgical-atlas/sites/default/files/public_files/PDF/Managing%20Complications%20Part%202-%20Patient%20and%20Family.pdf

Equitable and sustainable funding for community-based organisations in global mental health. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(23)00015-3/fulltext

Will a new wave of RSV vaccines stop the dangerous virus? Pfizer, GSK and Moderna are ahead in the race to produce vaccines against respiratory syncytial virus — what will be their impact? https://www.nature.com/articles/d41586-023-00212-z

Charting a course to make maths truly universal. Mathematicians leading decolonization efforts say that building knowledge-sharing partnerships with communities is key. https://www.nature.com/articles/d41586-023-00223-w

Revolt against educational rankings.https://www.science.org/doi/10.1126/science.adg8723

Undergraduate courses of evidence-based medicine in Peruvian medical schools: Characteristics and addressed topics. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00527-3

Health related quality of life of HIV-positive women on ART follow-up in north shewa zone public hospitals, central Ethiopia: Evidence from a cross-sectional study.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00525-X

Assessment of Microfinance Interventions and Intimate Partner Violence. A Systematic Review and Meta-analysis.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800854

One health systems strengthening in countries: Tripartite tools and approaches at the human-animal-environment interface. https://gh.bmj.com/content/8/1/e011236

Mean systolic blood pressure above the control threshold in people with treated uncontrolled hypertension: a pooled, cross-sectional analysis of 55 national health surveys. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00010-X/fulltext

Global Surgery: The Road Less Traveled and How to Get Back on Track.https://link.springer.com/article/10.1007/s00268-023-06920-x

31 JAN 2023

WHO: World is likely at an “inflexion point,” but covid remains public health emergency. https://www.bmj.com/content/380/bmj.p242

Annals On Call – Outpatient Treatment of COVID-19.https://www.acpjournals.org/doi/10.7326/A22-0003?utm_source=cmpnr&utm_campaign=lfa_230131_u&utm_content=1&cmp=1&utm_medium=email

COVID school closures cost children one-third of a year’s learning

A sustained catch-up effort is needed to help students to recover lost skills and knowledge. https://www.nature.com/articles/d41586-023-00274-z

The relationship between anxiety and smartphone addiction in the context of Covid-19: The mediating effect of attentional control and executive dysfunction.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00480-2

Insight into SARS-CoV-2 Omicron variant immune escape possibility and variant independent potential therapeutic opportunities.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00492-9

Prophylaxis and Treatment of SARS-CoV-2 infection by an ACE2 Receptor Decoy.https://www.cell.com/iscience/fulltext/S2589-0042(23)00169-4

Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800816

What do we know about the adaptive immune response to covid-19? https://www.bmj.com/content/380/bmj.p19

Multiomics single timepoint measurements to predict severe COVID-19. https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00251-5/fulltext

OTHER NEWS

A new angle on surgical resident wellness: exploring the correlation between emotional exhaustion, stress and performance-avoid goal orientation learning behaviors. https://link.springer.com/article/10.1007/s44186-022-00083-4

Sanctity. https://tinyurl.com/5jbc2ymw

Pharmaceutical industry relationships with oncologists in sub-Saharan Africa. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00639-8/fulltext

A call to create funding equity for researcher-mums. Mothers in academic research and those who support them say in a report that the funding system can and should remedy gender bias in the sciences. https://www.nature.com/articles/d41586-023-00252-5

Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesity. A 10-Year Follow-up of a Randomized Clinical Trial.https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2801011

Effects of a Polypill, Aspirin, and the Combination of Both on Cognitive and Functional Outcomes. A Randomized Clinical Trial. Results suggest that vascular risk factor modification may slow functional decline. https://jamanetwork.com/journals/jamaneurology/fullarticle/2800416

Associations Between Infant Screen Use, Electroencephalography Markers, and Cognitive Outcomes. Screen use during infancy may contribute to variations in neural activities implicated in the development of high-order cognitive skills. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2800776

Secondary data for global health digitalization.https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00195-9/fulltext

A critical interpretive synthesis of power and mistreatment of women in maternity care. https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000616

The integration of tuberculosis and HIV testing on GeneXpert can substantially improve access and same-day diagnosis and benefit tuberculosis programmes: A diagnostic network optimization analysis in Zambia.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001179

The development and implementation of a community engagement strategy to improve maternal health in southern Mozambique.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001106

“Mobilizing our leaders”: A multi-country qualitative study to increase the representation of women in global health leadership.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000646

Interventions for treating obstetric fistula: An evidence gap map. https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001481

The World Health Organization’s disease outbreak news: A retrospective database.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001083

1 Feb 2023

The next generation of coronavirus vaccines: a graphical guide. New technologies might provide more potent or broader immunity — but will have to fight for market share. https://www.nature.com/articles/d41586-023-00220-z

Numerical modeling of a sneeze, a cough and a continuum speech inside a hospital lift. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00577-7

Evaluation of altered miRNA expression pattern to predict COVID-19 severity.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00595-9

Trends, variation, and clinical characteristics of recipients of antiviral drugs and neutralising monoclonal antibodies for covid-19 in community settings: retrospective, descriptive cohort study of 23.4 million people in OpenSAFELY.https://bmjmedicine.bmj.com/content/2/1/e000276

Independent monitoring for the pandemic accord: a non-negotiable provision.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00126-5/fulltext?dgcid=raven_jbs_aip_email

Where infectious diseases erupt, and more — this week’s best science graphics. Three charts from the world of research, selected by Nature editors.https://www.nature.com/articles/d41586-023-00277-w

Could Africa be the future for genomics research? Funds for a major genomics programme in Africa will run dry this year. A chance to address global inequity in health-related genomics by building on the success of this initiative must not be missed. https://www.nature.com/articles/d41586-023-00222-x

Why we have nothing to fear from the decolonization of mathematics. Maths made the modern world — and everyone stands to gain from the acknowledgment that the world made maths. https://www.nature.com/articles/d41586-023-00240-9

Trustworthiness matters: Building equitable and ethical science.https://www.cell.com/cell/fulltext/S0092-8674(23)00008-9

Application of a highly simulated and adaptable training system in the laparoscopic training course for surgical residents: Experience from a high-volume teaching hospital in China. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00524-8

Effect of intraoperative blood transfusion on inflammatory response in parturients with placenta previa undergoing cesarean section: A prospective observational study.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00582-0

ProvOER Model: A Provenance Model for Open Educational Resources.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00518-2#%20

Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge. https://jamanetwork.com/journals/jama/fullarticle/2801170

2 Feb 2023

When will COVID stop being a global emergency?

The World Health Organization has decided the crisis isn’t over yet — but it’s at a transition point. https://www.nature.com/articles/d41586-023-00294-9

Hybrid Immunity More Protective Than Prior SARS-CoV-2 Infection Alone.https://jamanetwork.com/journals/jama/fullarticle/2801207

Reports of Guillain-Barré Syndrome After COVID-19 Vaccination in the United States.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800871?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=wklyforyou&utm_term=020123

Could a popular COVID-19 antiviral supercharge the pandemic? Merck & Co.’s molnupiravir appears to be speeding evolution of SARS-CoV-2. https://www.science.org/content/article/could-popular-covid-19-antiviral-supercharge-pandemic

Should COVID Vaccines Be Given Yearly? Some scientists say the U.S. Food and Drug Administration’s suggestion of updating COVID vaccines each year, as happens with influenza vaccines, could boost uptake. But others are less convinced.https://www.scientificamerican.com/article/should-covid-vaccines-be-given-yearly/

Angiotensin Converting Enzyme 2 – at the Heart of the COVID-19 pandemic.https://www.cell.com/cell/fulltext/S0092-8674(23)00098-3

Research on the novel medical protective clothing for COVID-19.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00581-9

Audio Interview: Updating and Standardizing Covid-19 Vaccines.https://www.nejm.org/doi/full/10.1056/NEJMe2301319?query=featured_home

Facing the New Covid-19 Reality.https://www.nejm.org/doi/full/10.1056/NEJMp2213920?query=featured_home

VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19.https://www.nejm.org/doi/full/10.1056/NEJMoa2208822?query=featured_home

Antiviral Agents against Omicron Subvariant BA.4.6 In Vitro.https://www.nejm.org/doi/full/10.1056/NEJMc2216611?query=featured_secondary

Newly Discovered Host-Cell Factor Could Be a COVID-19 Treatment Target.https://jamanetwork.com/journals/jama/fullarticle/2801202

Incidence of Chronic Spontaneous Urticaria Following Receipt of the COVID-19 Vaccine Booster in Switzerland.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800873

Covid-19: FDA removes US authorisation for antibody drug Evusheld.https://www.bmj.com/content/380/bmj.p264

Restoring and extending secondary prevention.https://www.bmj.com/content/380/bmj.p201

COVID-19 vaccine hesitancy among Nigerians living with non-communicable diseases: a qualitative study. https://bmjopen.bmj.com/content/13/2/e065901

Qualitative examination of collaboration in team-based primary care during the COVID-19 pandemic. https://bmjopen.bmj.com/content/13/2/e067208

High Infertility Rates and Pregnancy Complications in Female Physicians Indicate a Need for Culture Change.https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/High_Infertility_Rates_and_Pregnancy_Complications.3.aspx

Invited Commentary “High Infertility Rates and Pregnancy Complications in Female Physicians Indicate a Need for Culture Change”.https://journals.lww.com/annalsofsurgery/Citation/2023/03000/Invited_Commentary__High_Infertility_Rates_and.4.aspx

Routine Postsurgical Anesthesia Visit to Improve 30-day Morbidity and Mortality. A Multicenter, Stepped-wedge Cluster Randomized Interventional Study (The TRACE Study). The combination of MEWS and a postoperative anesthesia visit did not reduce 30-day mortality. https://tinyurl.com/z3u939k2

Making the Financial Case for Surgical Resident Well-being: A Scoping Review.https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/Making_the_Financial_Case_for_Surgical_Resident.8.aspx

“The Story I Will Never Forget”. Critical Incident Narratives in Surgical Residency.https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/_The_Story_I_Will_Never_Forget___Critical_Incident.30.aspx

Effective Senior Surgical Residents as Defined by Their Peers. A Qualitative Content Analysis of Nontechnical Skills Development.https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/Effective_Senior_Surgical_Residents_as_Defined_by.55.aspx

Improving Surgical Research Capacity in Low- and Middle-Income Countries. Can Episodic Data Collection Reliably Estimate Perioperative Mortality? Reliably tracking POMR does not require continuous data collection. Data driven sampling strategies can be used to decrease the burden of data collection to track POMR in resource-constrained settings. https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/Improving_Surgical_Research_Capacity_in_Low__and.56.aspx

Implementation of a Surgical Critical Care Service Reduces Failure to Rescue in Emergency Gastrointestinal Surgery in Rural Kenya.https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/Implementation_of_a_Surgical_Critical_Care_Service.57.aspx

If Aristotle Were a Surgeon. Phronetic Knowledge in Surgery. https://tinyurl.com/3wmvezu7

Surgical Informed Consent. A Scoping Review of Physician-facing Decision Support Tools. https://journals.lww.com/aosopen/Fulltext/2023/03000/Surgical_Informed_Consent__A_Scoping_Review_of.12.aspx?context=LatestArticles

Efficacy of three-dimensional models for medical education: A systematic scoping review of randomized clinical trials. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00602-3

Impact of interhospital transfer on emergency department timeliness of care and in-hospital outcomes of adult non-trauma patients.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00600-X#%20

Malaria — Epidemiology, Treatment, and Prevention.https://www.nejm.org/doi/full/10.1056/NEJMp2216703?query=featured_home

Antiretroviral Therapy and Adverse Pregnancy Outcomes in People Living with HIV.https://www.nejm.org/doi/full/10.1056/NEJMra2212877?query=featured_home

New HIV Vaccine Approach Safely Stimulated Rare Precursors to Broadly Neutralizing Antibodies. https://jamanetwork.com/journals/jama/fullarticle/2801201

Risk of Reoperation for Recurrence After Elective Primary Groin and Ventral Hernia Repair by Supervised Residents. The findings of this study suggest that supervised residents can safely perform elective open and laparoscopic repair of primary groin and ventral hernias without increased risk of reoperation. https://jamanetwork.com/journals/jamasurgery/fullarticle/2800979

Comment: Supervision and Transparency in Resident Training. https://jamanetwork.com/journals/jamasurgery/fullarticle/2800985

Association of Resident Independence With Short-term Clinical Outcome in Core General Surgery Procedures. Core general surgery cases performed by senior-level trainees in such a way that the attending physician is not scrubbed into the case are being done safely with no significant difference in rates of postoperative complication. https://jamanetwork.com/journals/jamasurgery/fullarticle/2800980

Adverse pregnancy outcomes and long term risk of ischemic heart disease in mothers: national cohort and co-sibling study. https://www.bmj.com/content/380/bmj-2022-072112

How quickly does COVID immunity fade? What scientists know. Vaccination, infection with SARS-CoV-2 and a combination of both provide varying degrees of protection.New evidence suggests that ‘hybrid’ immunity, the result of both vaccination and a bout of COVID-19, can provide partial protection against reinfection for at least eight months1. It also offers greater than 95% protection against severe disease or hospitalization for between six months and a year after an infection or vaccination, according to estimates from a meta-analysis2. Immunity acquired by booster vaccination alone seems to fade somewhat faster. https://www.nature.com/articles/d41586-023-00124-y

Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2. https://www.cell.com/iscience/fulltext/S2589-0042(23)00203-1

Tocilizumab treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants. https://www.cell.com/iscience/fulltext/S2589-0042(23)00201-8

Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study.https://bmjopen.bmj.com/content/13/2/e063141

Qualitative examination of collaboration in team-based primary care during the COVID-19 pandemic. https://bmjopen.bmj.com/content/13/2/e067208

OTHER NEWS

Extent of Lymphadenectomy and Long-term Survival in Esophageal Cancer. https://journals.lww.com/annalsofsurgery/Abstract/2023/03000/Extent_of_Lymphadenectomy_and_Long_term_Survival.13.aspx

ChatGPT: five priorities for research. Conversational AI is a game-changer for science. Here’s how to respond. https://www.nature.com/articles/d41586-023-00288-7

Factors associated with complications of foreign body ingestion and/or aspiration in children from a Peruvian hospital. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00657-6

Comparisons of Severe Maternal Morbidity and Other Adverse Pregnancy Outcomes in Pregnant People With Sickle Cell Disease vs Anemia.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800896

Severe Maternal Morbidity and Mortality in Sickle Cell Disease in the National Inpatient Sample, 2012-2018.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800895

Management of mammalian bites. https://www.bmj.com/content/380/bmj-2022-071921

Development of indicators for integrated antenatal care service provision: a feasibility study in Burkina Faso, Kenya, Malawi, Senegal and Sierra Leone.https://bmjopen.bmj.com/content/13/2/e065358

Femoral Venous Cutdown. https://www.vumc.org/global-surgical-atlas/sites/default/files/public_files/PDF/Femoral%20Venous%20Cutdown.pdf

Global cancer: overcoming the narrative of despondency.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00234-9/fulltext?dgcid=raven_jbs_etoc_email

Postoperative antibiotics can be de-escalated after laparoscopic surgery for complex appendicitis. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02544-2/fulltext?dgcid=raven_jbs_etoc_email

Health literacy exists beyond the boundaries of medicine.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00008-9/fulltext?dgcid=raven_jbs_etoc_email

When dignity meets evidence. The art of medicine. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00176-9/fulltext

The future of global health research, publishing, and practice.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(23)00010-4/fulltext

50 Nutrition and Child Health Organisations Support Important WHO Initiative on Food Fortification. https://www.gainhealth.org/media/news/50-nutrition-and-child-health-organisations-support-important-who-initiative-food

Development of a Red Flag Scorecard Screening Tool for the Identification of Child Physical Abuse in the Emergency Department. https://www.jpedsurg.org/article/S0022-3468(23)00076-3/fulltext

Chelsea Watego: foregrounding Indigenous intellectual sovereignty.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00173-3/fulltext

Behind-the-Scenes Investment for Equity in Global Health Research.https://www.nejm.org/doi/pdf/10.1056/NEJMp2213809?articleTools=true

6 Feb 2023

Physical interventions to interrupt or reduce the spread of respiratory viruses.https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006207.pub6/full

A multistate model and its standalone tool to predict hospital and ICU occupancy by patients with COVID-19. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00752-1

Improved autoregressive integrated moving average model for COVID-19 prediction by using statistical significance and clustering techniques.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00690-4

Chinese digestive surgery interns’ learning quality and English reading proficiency during COVID-19 pandemic: Comparison between face-to-face versus WeChat teaching and learning. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00641-2

Probing the Affinity of Noble Metal Nanoparticles to the Segments of the SARS-CoV-2 Spike Protein. https://www.cell.com/iscience/fulltext/S2589-0042(23)00187-6

Estimation of Vaccine Effectiveness of CoronaVac and BNT162b2 Against Severe Outcomes Over Time Among Patients With SARS-CoV-2 Omicron. These findings suggest that a booster dose should be recommended to older individuals to restore immunity, and this is especially urgent for a setting like Hong Kong, where third-dose coverage is still insufficient among older residents. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800935

Role of individual characteristics and national distancing policies for COVID-19 protective behaviour among older adults: a cross-sectional study of 27 European countries. https://bmjopen.bmj.com/content/13/2/e060291

Outcome predictors and patient progress following delivery in pregnant and postpartum patients with severe COVID-19 pneumonitis in intensive care units in Israel (OB-COVICU): a nationwide cohort study.https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00491-X/fulltext

Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial.https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(23)00020-2/fulltext

Global antibiotic use during the COVID-19 pandemic: analysis of pharmaceutical sales data from 71 countries, 2020–2022.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00025-1/fulltext

OTHER NEWS

Global cancer: overcoming the narrative of despondency.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00234-9/fulltext

The myth of academic indoctrination. https://www.science.org/content/blog-post/myth-academic-indoctrination

An analysis of existing national action plans for antimicrobial resistance—gaps and opportunities in strategies optimising antibiotic use in human populations.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(23)00019-0/fulltext?dgcid=raven_jbs_aip_email

Perceptions of employers in South Africa on library and information science graduates’ skills, knowledge and competencies on digital scholarship. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00738-7

What is appropriate care? A qualitative study into the perceptions of healthcare professionals in Flemish university hospital intensive care units.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00678-3

Design of a postpartum hemorrhage and transfusion risk calculator. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00635-7#%20

Introduction of the Ellavi uterine balloon tamponade into the Kenyan and Ghanaian maternal healthcare package for improved postpartum haemorrhage management: an implementation research study. https://bmjopen.bmj.com/content/13/2/e066907

FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate. https://bmjopen.bmj.com/content/13/2/e067142

Evaluation of the practice of surgical antibiotic prophylaxis in a Zonal Referral Hospital in Mbujimayi, Democratic Republic of the Congo (DRC). https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-023-01926-7

Transvaginal natural orifice transluminal endoscopic surgery versus conventional vaginal surgery for sacrospinous ligament fixation of apical compartment prolapse: a retrospective analysis. https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-023-01921-y

Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(23)00004-9/fulltext

Pregnancy and neonatal safety outcomes of timing of initiation of daily oral tenofovir disoproxil fumarate and emtricitabine pre-exposure prophylaxis for HIV prevention (CAP016): an open-label, randomised, non-inferiority trial.https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00369-1/fulltext

Change in body weight and risk of hypertension after switching from efavirenz to dolutegravir in adults living with HIV: evidence from routine care in Johannesburg, South Africa. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00013-5/fulltext

Ethical implications of economic compensation for voluntary medical male circumcision for HIV prevention and epidemic control.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001361

7 Feb 2023

What the WHO’s new treaty could mean for the next pandemic. A draft of the agreement highlights vaccine and drug equity but lacks teeth to enforce it, say researchers. https://www.nature.com/articles/d41586-023-00358-w

A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile.. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00047-2

Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800885

Excess Mortality Among US Physicians During the COVID-19 Pandemic. From March 2020 through December 2021, US physicians experienced 622 more deaths than expected. There were no excess deaths among physicians after April 2021, coinciding with the widespread availability of COVID-19 vaccines. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800889

The COVID-19 e-lective: using innovation to manage disrupted medical student clinical placements. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04067-w

Mediating role of psychological distress and domestic violence in the association of fear of COVID-19 with marital satisfaction and sexual quality of life among women of reproductive age: An Iranian cross-sectional study.https://bmjopen.bmj.com/content/13/2/e068916

OTHER NEWS

Historical determinants of neurosurgical inequities in Africa and the African diaspora: A review and analysis of coloniality.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001550

What ChatGPT and generative AI mean for science. Researchers are excited but apprehensive about the latest advances in artificial intelligence.https://www.nature.com/articles/d41586-023-00340-6

Virus exposure and neurodegenerative disease risk across national biobanks.https://www.cell.com/neuron/fulltext/S0896-6273(22)01147-3?utm_medium=homepage

Rotational thromboelastometry during Cesarean section as a predictive evaluation for the progression of persistent postpartum hemorrhage in parturients with placenta previa: A prospective observational study. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00770-3

Global historical retrospect and future prospects on biomarkers of heart failure: A bibliometric analysis and science mapping.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00716-8

How to engage patients in achieving patient safety: A qualitative study from healthcare professionals’ perspective. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00654-0

Effect of Antibiotic Prescription Audit and Feedback on Antibiotic Prescribing in Primary Care. A Randomized Clinical Trial. Among primary care physicians with medium to high antibiotic prescription rates, antibiotic prescribing audit and feedback did not reduce antibiotic prescribing. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800887

Impact of breastfeeding on the incidence and severity of respiratory syncytial virus (RSV)-associated acute lower respiratory infections in infants: a systematic review highlighting the global relevance of primary prevention.https://gh.bmj.com/content/8/2/e009693

Medicalisation of female genital mutilation is a dangerous development.https://www.bmj.com/content/380/bmj.p302

How can I deal with guilt over being off work sick?https://www.bmj.com/content/380/bmj.p109

Accuracy of efficient data methods to determine the incidence of hospital-acquired thrombosis and major bleeding in medical and surgical inpatients: a multicentre observational cohort study in four UK hospitals.https://bmjopen.bmj.com/content/13/2/e069244

Health literacy levels in patients with type 2 diabetes in an affluent Gulf country: a cross-sectional study. https://bmjopen.bmj.com/content/13/2/e069489

Characterising paediatric mortality during and after acute illness in Sub-Saharan Africa and South Asia: a secondary analysis of the CHAIN cohort using a machine learning approach. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00015-9/fulltext

Conference equity in global health: a systematic review of factors impacting LMIC representation at global health conferences.https://gh.bmj.com/content/6/1/e003455.long

“It is like an umbrella covering you, yet it does not protect you from the rain”: a mixed methods study of insurance affordability, coverage, and financial protection in rural western Kenya. https://equityhealthj.biomedcentral.com/articles/10.1186/s12939-023-01837-2

8 Feb 2023

COVID drug drives viral mutations — and now some want to halt its use. Analysis reveals the signature of the antiviral drug molnupiravir in SARS-CoV-2 sequences riddled with mutations. The study was posted on the medRxiv preprint server in January. It has not yet been peer reviewed. https://www.nature.com/articles/d41586-023-00347-z

Global pandemic treaty: what we must learn from climate-change errors. The WHO’s draft agreement proposes a COP-like process. That’s unlikely to improve on the world’s disastrous COVID response. https://www.nature.com/articles/d41586-023-00339-z

Critics of risky virus studies launch nonprofit to push for research halt, tighter safety rules. Group says strict laws are needed to prevent a lab-caused pandemic.https://www.science.org/content/article/critics-risky-virus-studies-launch-nonprofit-push-research-halt-tighter-safety-rules

Masks thermal degradation as an alternative of waste valorization on the COVID-19 pandemic: A kinetic study. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00725-9

Impact of online learning on sense of belonging among first year clinical health students during COVID-19: student and academic perspectives.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04061-2

Anxiety and stress among healthcare professionals during COVID-19 in Ethiopia: systematic review and meta-analysis. https://bmjopen.bmj.com/content/13/2/e070367

Associations of the COVID-19 pandemic with quality of life: A cross-sectional study of older-age people with and without HIV in rural Uganda. https://jogh.org/2023/jogh-13-06003

OTHER NEWS

Measuring societal impact: how to go beyond standard publication metrics. Approaches to capturing the benefits of research on society are improving — but huge challenges remain. https://www.nature.com/articles/d41586-023-00345-1

The effect of evening primrose oil on cervical ripening and birth outcomes: A systematic review and meta-analysis. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00621-7#%20

Four-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy. At 4 years, treatment of NPDR with aflibercept vs sham treatment resulted in statistically significant anatomic improvement, but no improvement in visual acuity. https://jamanetwork.com/journals/jama/fullarticle/2801058

The Uncertain Future of the Determination of Brain Death.https://jamanetwork.com/journals/jama/fullarticle/2801417

It’s Time to Rebrand “Mommy Brain”.https://jamanetwork.com/journals/jamaneurology/fullarticle/2801288

Anti–Vascular Endothelial Growth Factor Therapy for Complications of Diabetic Retinopathy—From Treatment to Prevention?https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2801416

US Infant Pertussis Incidence Trends Before and After Implementation of the Maternal Tetanus, Diphtheria, and Pertussis Vaccine. These findings suggest that maternal Tdap vaccination is associated with a reduction in pertussis among infants younger than 2 months, the strategy’s target age group. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2801085

Health and economic benefits of achieving contraceptive and maternal health targets in Small Island Developing States in the Pacific and Caribbean.https://gh.bmj.com/content/8/2/e010018

Interventions to increase mammography screening uptake among women living in low-income and middle-income countries: a systematic review.https://bmjopen.bmj.com/content/13/2/e066928

JoGH policy on the use of artificial intelligence in scholarly manuscripts.https://jogh.org/2023/jogh-13-01002

Systematic review on the impact of the pneumococcal conjugate vaccine ten valent (PCV10) or thirteen valent (PCV13) on all-cause, radiologically confirmed and severe pneumonia hospitalisation rates and pneumonia mortality in children 0-9 years old.https://jogh.org/2023/jogh-13-05002

The ability of non-physician health workers to identify chest indrawing to detect pneumonia in children below five years of age in low- and middle-income countries: A systematic review and meta-analysis. https://jogh.org/2023/jogh-13-04016

Global reporting of progress towards elimination of hepatitis B and hepatitis C.https://www.thelancet.com/journals/langas/article/PIIS2468-1253(22)00386-7/fulltext

Effects of clinical, comorbid, and social determinants of health on brain ageing in people with and without HIV: a retrospective case-control study.https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00373-3/fulltext

Surgery risks are disproportionately high for women in Africa – new study.https://theconversation.com/surgery-risks-are-disproportionately-high-for-women-in-africa-new-study-198887 Postoperative outcomes associated with surgical care for women in Africa: an international risk-adjusted analysis of prospective observational cohorts. https://www.sciencedirect.com/science/article/pii/S2772609622000995#!

Breastfeeding 2023. Lancet series. https://www.thelancet.com/series/Breastfeeding-2023

9 Feb 2023

New COVID Antiviral Cuts Hospitalizations in Half. An injection of a type of interferon drastically reduced the risk of severe COVID in a late-stage trial.https://www.scientificamerican.com/article/new-covid-antiviral-cuts-hospitalizations-in-half/

Early Treatment with Pegylated Interferon Lambda for Covid-19.https://www.nejm.org/doi/full/10.1056/NEJMoa2209760?query=featured_home

Bivalent Covid-19 Vaccines — A Cautionary Tale.https://www.nejm.org/doi/full/10.1056/NEJMp2215780?query=featured_home

Antibody Response to Omicron BA.4–BA.5 Bivalent Booster.https://www.nejm.org/doi/full/10.1056/NEJMc2213907?query=featured_home

Updated COVID-19 Guidance for People Who Are Immunocompromised.https://jamanetwork.com/journals/jama/fullarticle/2801507

Public Health Workers Report Threats, Harassment During Pandemic.https://jamanetwork.com/journals/jama/fullarticle/2801505

Paxlovid Alternative Is Similarly Effective.https://jamanetwork.com/journals/jama/fullarticle/2801504

Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study.https://www.bmj.com/content/380/bmj-2022-074035

OTHER NEWS

Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth. Among women planning a vaginal delivery, a single oral dose of azithromycin resulted in a significantly lower risk of maternal sepsis or death than placebo but had little effect on newborn sepsis or death. https://www.nejm.org/doi/full/10.1056/NEJMoa2212111?query=main_nav_lg

Single-dose antibiotic prevents maternal sepsis and death. Results of NIH-funded study suggest a potential approach to reduce maternal mortality in low- and middle-income countries. https://www.nih.gov/news-events/news-releases/single-dose-antibiotic-prevents-maternal-sepsis-death?utm_source=dlvr.it&utm_medium=twitter

Hidden harms of indoor air pollution — five steps to expose them. Dirty outdoor air might grab the headlines, but learning how pollutants inside buildings form, accumulate and affect our health is equally crucial.https://www.nature.com/articles/d41586-023-00287-8

Twitter’s plan to cut off free data access evokes ‘fair amount of panic’ among scientists. Social media platform’s intent to increase revenue could end or limit many research projects. https://www.science.org/content/article/twitters-plan-cut-free-data-access-evokes-fair-amount-panic-among-scientists

Evaluation of coronary stents: A review of types, materials, processing techniques, design, and problems. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00782-X#%20

Malaria — Epidemiology, Treatment, and Prevention.https://www.nejm.org/doi/full/10.1056/NEJMp2216703?query=featured_home

Bird Flu Has Begun to Spread in Mammals—Here’s What’s Important to Know.https://jamanetwork.com/journals/jama/fullarticle/2801499

Healthful Lifestyle May Slow Memory Loss, Even for APOE Gene Carriers. However, the authors of a corresponding editorial cautioned that it’s unclear whether the findings are clinically meaningful or at what age a healthful lifestyle becomes important for slowing memory change. https://jamanetwork.com/journals/jama/fullarticle/2801508

Lifetime Traumatic Brain Injury and Cognitive Domain Deficits in Late Life: The PROTECT-TBI Cohort Study. https://www.liebertpub.com/doi/10.1089/neu.2022.0360 Even Mild Concussions Tied to Worse Cognition Later in Life.https://jamanetwork.com/journals/jama/fullarticle/2801502

Financial Toxicity Among Patients With Breast Cancer Worldwide

A Systematic Review and Meta-analysis. The majority were undertaken in HICs (24 studies)…A total of 10 studies were from LMICs, including China (2 studies), India (2 studies), Haiti (1 study), Kenya (1 study), Nigeria (1 study), Egypt (1 study), Iran (1 study), and 1 study examining multiple Southeast Asian countries. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801099

Development of an Enhanced Recovery After Surgery Surgical Safety Checklist Through a Modified Delphi Process. One author is from South Africa. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801109

The impact of economic sanctions on health and health systems in low-income and middle-income countries: a systematic review and narrative synthesis.https://gh.bmj.com/content/8/2/e010968

Multimorbidity of cardiometabolic diseases: a cross-sectional study of patterns, clusters and associated risk factors in sub-Saharan Africa. https://bmjopen.bmj.com/content/13/2/e064275

Socioeconomic factors associated with the number of children ever born by married Ghanaian females: a cross-sectional analysis.https://bmjopen.bmj.com/content/13/2/e067348

Effectiveness of the perioperative encounter in promoting regular exercise and physical activity: a systematic review and meta-analysis. Interventions delivered in the perioperative setting, aimed at enhancing PA in the medium to long-term, may have overall benefit. However, because of imprecision in some of the findings, we could not rule out the possibility of no change in PA. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00535-1/fulltext

Transvesical (Suprapubic) Prostatectomy. https://www.vumc.org/global-surgical-atlas/sites/default/files/public_files/PDF/Trans-vesical%20%28Suprapubic%29%20Prostatectomy.pdf

Results of NIH-funded study suggest a potential approach to reduce maternal mortality in low- and middle-income countries. https://www.nih.gov/news-events/news-releases/single-dose-antibiotic-prevents-maternal-sepsis-death?utm_source=dlvr.it&utm_medium=twitter

Transnational Capacity Building Efforts in Global Neurosurgery: A Review and Analysis of Their Impact and Determinants of Success.https://www.sciencedirect.com/science/article/abs/pii/S1878875023001365?via%3Dihub

10 Feb 2023

In silico anti-SARS-CoV-2, antiplasmodial, antioxidant, and antimicrobial activities of crude extracts and homopterocarpin from heartwood of Pterocarpus macrocarpus Kurz. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00851-4

COVID-19 and tuberculosis coinfection: An overview of case reports/case series and meta-analysis of prevalence studies. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00844-7

Performance characteristics of the boson rapid SARS–cov–2 antigen test card vs RT–PCR: Cross–reactivity and emerging variants.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00849-6

Language and COVID-19: A discourse analysis of resistance to lockdown in Indonesia.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00758-2

Pneumocystis pneumonia in COVID-19 patients: A comprehensive review.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00825-3

SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection.https://www.cell.com/iscience/fulltext/S2589-0042(23)00252-3

OTHER NEWS

A Common Antibiotic Could Prevent Deaths from Childbirth Complications. One in three cases of maternal sepsis can be prevented with a single dose of antibiotic, a study in low- and middle-income countries shows.https://www.scientificamerican.com/article/a-common-antibiotic-could-prevent-deaths-from-childbirth-complications/

Association Between Antimicrobial Stewardship Programs and Antibiotic Use Globally. A Systematic Review and Meta-Analysis.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801197

Complication Rate of Percutaneous Dilatational Tracheostomy in Critically Ill Adults With Obesity. A Systematic Review and Meta-analysis.https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2801482

Total Intravenous Anesthesia and Postoperative Pulmonary Complications.https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2801487 Total Intravenous Anesthesia and Postoperative Pulmonary Complications—Reply.https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2801484

Association Between Endotracheal Tube Size and Outcomes in Critically Ill Patients.https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2801486

From the Global North to the Global South: preparing students for away rotations.https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04085-8

Cholera: Malawi is in grip of its deadliest outbreak.https://www.bmj.com/content/380/bmj.p328

Scarlett McNally: Surgical checklists help improve patient safety and teamworking.https://www.bmj.com/content/380/bmj.p279

Early diagnosis of cancer: systems approach to support clinicians in primary care.https://www.bmj.com/content/380/bmj-2022-071225

Safety and efficacy of once-weekly basal insulin Fc in people with type 2 diabetes previously treated with basal insulin: a multicentre, open-label, randomised, phase 2 study. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00388-6/fulltext

Long-term evolution of comorbidities and their disease burden in individuals with and without HIV as they age: analysis of the prospective AGEhIV cohort study.https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(22)00400-3/fulltext

Quantifying the effect of delaying the second COVID-19 vaccine dose in England: a mathematical modelling study.https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00337-1/fulltext

13 Feb 2023

Protecting infants through covid-19 vaccination during pregnancy.https://www.bmj.com/content/380/bmj.p241

COVID Rebound Can Happen Even without Paxlovid. Concerns about Paxlovid rebound are preventing some doctors from prescribing the lifesaving drug and some high-risk patients from taking it. https://www.scientificamerican.com/article/covid-rebound-can-happen-even-without-paxlovid/

Cost-effectiveness of fractional doses of COVID-19 vaccine boosters in India.https://www.cell.com/med/fulltext/S2666-6340(23)00061-2

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike. https://www.cell.com/cell/fulltext/S0092-8674(23)00103-4

Establishing local manufacture of PPE for healthcare workers in the time of a global pandemic. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00556-X

Investigating the effect of vaccinated population on the COVID-19 prediction using FA and ABC-based feed-forward neural networks.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00879-4

Exposure to airborne SARS-CoV-2 in four hospital wards and ICUs of Cyprus. A detailed study accounting for day-to-day operations and aerosol generating procedures. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00876-9

Student adjustment during Covid-19 pandemic: Exploring the moderating role of university support. (Ghana) https://www.cell.com/heliyon/fulltext/S2405-8440(23)00832-0

Influence of the COVID-19 pandemic and social media on the behaviour of pregnant and lactating women towards vaccination: a scoping review.https://bmjopen.bmj.com/content/13/2/e066367

Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up to December, 2022.https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00015-2/fulltext

OTHER NEWS

Contemporary medical, device, and surgical therapies for obesity in adults.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02403-5/fulltext?utm_campaign=therapeutics&utm_source=twitter&utm_medium=social

Eight countries eliminated a neglected tropical disease in 2022. Mass treatment programmes and a focus on hygiene and hand washing helped some nations to banish the illnesses. Malawi, Vanuatu and Uganda were among the eight nations that eliminated a neglected tropical disease last year, according to a World Health Organization (WHO) report. https://www.nature.com/articles/d41586-023-00286-9

WHO may soon end mpox emergency — but outbreaks rage in Africa. African health officials worry that as the mpox outbreak wanes in wealthy countries, so too will the global interest in research and funding. https://www.nature.com/articles/d41586-023-00391-9

Antimalarial activity of the 80%methanol extract and solvent fractions of Cucumis ficifolius A. rich roots against Plasmodium berghei in mice.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00897-6

Investigating the trend of road traffic fatalities in Malawi using Mann-Kendall statistic.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00907-6

Evaluation of the accuracy of established patient inspiratory effort estimation methods during mechanical support ventilation. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00817-4#%20

A Semistructured Interview for Surgical Residency Targeting Nontechnical Skills. (From Tenwek Hospital, Bomet, Kenya). https://www.sciencedirect.com/science/article/abs/pii/S1931720422001799

Association of the time in targeted blood glucose range of 3.9–10 mmol/L with the mortality of critically ill patients with or without diabetes.https://www.cell.com/heliyon/fulltext/S2405-8440(23)00869-1

A new inexpensive ultrasound-guided central venous catheterization simulation model. https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-023-04080-z

Barriers to family planning use in the Eastern Democratic Republic of the Congo: an application of the theory of planned behaviour using a longitudinal survey.https://bmjopen.bmj.com/content/13/2/e061564

Association between obesity and 1-year mortality in septic patients: a retrospective cohort study. https://bmjopen.bmj.com/content/13/2/e066526

Healthcare waste management practice and its predictors among health workers in private health facilities in Ilu Aba Bor Zone, Oromia region, South West Ethiopia: a community-based cross-sectional study.https://bmjopen.bmj.com/content/13/2/e067752

Multimorbidity of cardiometabolic diseases: a cross-sectional study of patterns, clusters and associated risk factors in sub-Saharan Africa.https://bmjopen.bmj.com/content/13/2/e064275

Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00033-6/fulltext

Visa discrimination: moving beyond global health.https://blogs.bmj.com/bmjgh/2023/02/12/visa-discrimination-moving-beyond-global-health/

14 Feb 2023

Delta-Omicron recombinant escapes therapeutic antibody neutralization.https://www.cell.com/iscience/fulltext/S2589-0042(23)00152-9

Incidence, Risk, and Severity of SARS-CoV-2 Reinfections in Children and Adolescents Between March 2020 and July 2022 in Serbia.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801348

Dengue amid COVID-19 pandemic. https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001558

Conflicting COVID-19 excess mortality estimates.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00112-5/fulltext

OTHER NEWS

Stop the peer-review treadmill. I want to get off. Faced with a deluge of papers, journal editors are struggling to find willing peer reviewers.https://www.nature.com/articles/d41586-023-00403-8

Heeding the happiness call: why academia needs to take faculty mental health more seriously. Group leaders voice their struggles with mental health to remove stigma and bolster institutional support. https://www.nature.com/articles/d41586-023-00419-0

Comparison of Distal Radius Fracture Outcomes in Older Adults Stratified by Chronologic vs Physiologic Age Managed With Casting vs Surgery.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801347

Why would they spend all this money and give us these items for free?’: Exploring precarity and power in a cleaner cookstove intervention in rural Malawi.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001537

Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors. https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0001459

Epigenome-wide association study of plasma lipids in West Africans: the RODAM study. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00034-8/fulltext#%20

Image-based surgical site infection algorithms to support home-based post-cesarean monitoring: Lessons from Rwanda.https://journals.plos.org/globalpublichealth/article/authors?id=10.1371/journal.pgph.0001584

The utilization of clinical decision support tools to identify neonatal hypothermia and its associated risk factors: A prospective observational study.https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000982

15 Feb 2023

WHO abandons plans for crucial second phase of COVID-origins investigation. Sensitive studies in China were intended to pinpoint the source of the pandemic virus.https://www.nature.com/articles/d41586-023-00283-y

Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments. The causes of long COVID, which disables millions, may come together in the brain and nervous system. https://www.scientificamerican.com/article/long-covid-now-looks-like-a-neurological-disease-helping-doctors-to-focus-treatments/

Continuously-deformable and stiffness-tunable soft manipulator achieving unmanned COVID-19 pandemic sampling. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00938-6

Delta-Omicron recombinant escapes therapeutic antibody neutralization.https://www.cell.com/iscience/fulltext/S2589-0042(23)00152-9#%20

Early vs Deferred Non–Messenger RNA COVID-19 Vaccination Among Chinese Patients With a History of Inactive Uveitis. A Randomized Clinical Trial.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801412

Identification of Bradycardia Following Remdesivir Administration Through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic Pharmacovigilance Project.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801411

Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801415

Covid-19: WHO treaty hopes to overcome “catastrophic failures” of pandemic response. https://www.bmj.com/content/380/bmj.p357

John Launer: Wishing upon a tsar—covid and health literacy.https://www.bmj.com/content/380/bmj.p331

OTHER NEWS

IAS – the International AIDS Society – today announced that the International AIDS Conference, the IAS Conference on HIV Science and the HIV Research for Prevention Conference will rotate to all regions of the world and that conferences will continue to offer virtual participation. Munich, Germany, will host AIDS 2024; the IAS will invite bids from Africa for IAS 2025 and from Latin America and the Caribbean for AIDS 2026. https://www.iasociety.org/news/ias-announces-global-rotation-all-its-conferences

AI chatbots are coming to search engines – can you trust the results? Google, Microsoft and Baidu are using tools like ChatGPT to turn internet search into a conversation. How will this change humanity’s relationship with machines?https://www.nature.com/articles/d41586-023-00423-4

Effects of psychosocial interventions for caregivers of breast cancer patients: A systematic review and meta-analysis. https://www.cell.com/heliyon/fulltext/S2405-8440(23)00922-2

STATISTICS AND RESEARCH METHODS. Introducing the Library of Guidance for Health Scientists (LIGHTS). A Living Database for Methods Guidance.https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801408

Interventions to reintroduce or increase assisted vaginal births: a systematic review of the literature. https://bmjopen.bmj.com/content/13/2/e070640

Urogenital schistosomiasis (UGS) and female genital schistosomiasis (FGS) in Cameroon: an observational assessment of key reproductive health determinants of girls and women in the Matta Health Area.https://bmjopen.bmj.com/content/13/2/e063392

Systematic review of intervention functions, theoretical constructs and cultural adaptations of school-based smoking prevention interventions in low-income and middle-income countries. https://bmjopen.bmj.com/content/13/2/e066613

Modern contraceptive utilisation and its associated factors among reproductive age women in high fertility regions of Ethiopia: a multilevel analysis of Ethiopia Demographic and Health Survey. https://bmjopen.bmj.com/content/13/2/e066432

Frequency and distribution of ABO and Rh blood group systems among blood donors at the Northern Zone Blood Transfusion Center in Kilimanjaro, Tanzania: a retrospective cross-sectional study. https://bmjopen.bmj.com/content/13/2/e068984

Performance of standardised colposcopy to detect cervical precancer and cancer for triage of women testing positive for human papillomavirus: results from the ESTAMPA multicentric screening study.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00545-9/fulltext

Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women’s and Children’s Health Research.In 2020, the ASPIRIN trial showed the efficacy of low-dose aspirin (LDA) in nulliparous, singleton pregnancies for the prevention of preterm birth. We sought to investigate the cost-effectiveness of this therapy in low-income and middle-income countries. In model simulations, LDA was associated with 141 averted preterm births, 74 averted perinatal deaths, and 31 averted hospitalisations per 10 000 pregnancies. The reduction in hospitalisation resulted in a cost of US$248 per averted preterm birth, $471 per averted perinatal death, and $15·95 per disability-adjusted life year. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00548-4/fulltext

Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00549-6/fulltext

The 1/4/6×24 campaign to cure tuberculosis quickly.https://www.nature.com/articles/s41591-022-02136-z

Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study.https://www.bmj.com/content/380/bmj-2022-072691

The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02469-2/fulltext

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00793-9/fulltext

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